The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Effect of Lithospermum Erythrorhizon on the Atopic Dermatitis

자초(紫草)가 아토피 피부염에 미치는 영향

  • Kim, Shi-Hye (Department of Pediatrics, College of Oriental Medicine, Kyung Hee University) ;
  • Jung, Hyuk-Sang (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Jin-Yong (Department of Pediatrics, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Deog-Gon (Department of Pediatrics, College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Baek-Gun (Department of Pediatrics, College of Oriental Medicine, Kyung Hee University)
  • 김시혜 (경희대학교 한의과대학 소아과교실) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실) ;
  • 이진용 (경희대학교 한의과대학 소아과교실) ;
  • 김덕곤 (경희대학교 한의과대학 소아과교실) ;
  • 조백건 (경희대학교 한의과대학 소아과교실)
  • Published : 2004.08.31
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Abstract

Objective: Atopic dermatitis has a close relationship with degranulation of mast cell and separation of histamine. As there was no experiment with herb, using Lithospermum erythrorhizon, We investigated experimental influence of Lithospermum erythrorhizon on degranulation of mast cell and separation of histamine in Sprague-Dawley rats. Methods: The SD rats were classified into three groups. One group was a normal one treated by normal saline before medical treatment. The other was a control group prescribed to Compound 48/80 before normal saline treatment. And the third was a expenimental group prescribed to compound 48/80 after medical treatment of Lithospermum erythrorhizon. Then, We investigated the experimental results by measuring the degree of degranulation and separation of histamine. Results: Lithospermum erythrorhizon did obviously inhibit the degree of degranulation of mast cell(p<0.05). Lithospermum erythrorhizon inhibited the separation of histamine in the plasma. Conclusion: Lithospermum erythrorhizon may be one of the effective therapeutic regimens on atopic dermatitis.

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