Tuberculosis and Respiratory Diseases
- 제55권5호
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- Pages.478-487
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- 2003
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
특발성 폐섬유화증 환자의 치료에서 Angiotensin II Receptor Antagonist의 치료효과
The Therapeutic Effect of Angiotensin II Receptor Antagonist in Idiopathic Pulmonary Fibrosis
- 우덕수 (가천의대 길병원 호흡기내과) ;
- 설원종 (가천의대 길병원 호흡기내과) ;
- 경선영 (가천의대 길병원 호흡기내과) ;
- 임영희 (가천의대 길병원 호흡기내과) ;
- 안창혁 (가천의대 길병원 호흡기내과) ;
- 박정웅 (가천의대 길병원 호흡기내과) ;
- 정성환 (가천의대 길병원 호흡기내과) ;
- 이재웅 (가천의대 길병원 흉부외과)
- Woo, Duck Soo (Division of Pulmonary Medicine, Department of Internal Medicine, Gachon Medical School Gil Medical Center) ;
- Seol, Won Jong (Division of Pulmonary Medicine, Department of Internal Medicine, Gachon Medical School Gil Medical Center) ;
- Kyung, Sun Young (Division of Pulmonary Medicine, Department of Internal Medicine, Gachon Medical School Gil Medical Center) ;
- Lim, Young Hee (Division of Pulmonary Medicine, Department of Internal Medicine, Gachon Medical School Gil Medical Center) ;
- An, Chang Hyeok (Division of Pulmonary Medicine, Department of Internal Medicine, Gachon Medical School Gil Medical Center) ;
- Park, Jeong Woong (Division of Pulmonary Medicine, Department of Internal Medicine, Gachon Medical School Gil Medical Center) ;
- Jeong, Sung Hwan (Division of Pulmonary Medicine, Department of Internal Medicine, Gachon Medical School Gil Medical Center) ;
- Lee, Jae Woong (Division of Pulmonary Medicine, Department of Thoracic Surgery, Gachon Medical School Gil Medical Center)
- 발행 : 2003.11.30
초록
연구배경 : Angiotensin II가 폐포상피세포의 세포사멸을 유도하고 폐섬유모세포에서 TGF-
Background : There have been several studies showing that the angiotensin II and angiotensin converting enzyme(ACE) contributes to the apoptosis of alveolar epithelial cells in idiopathic interstitial pneumonia and the activation of fibroblasts during the process of pulmonary fibrosis. These results suggest that the pulmonary fibrosis can be inhibited by the angiotensin II receptor antagonist(AGIIRA). This study was performed to identify the therapeutic effect of AGIIRA in idiopathic pulmonary fibrosis(IPF). Method : Thirteen patients with IPF, who were diagnosed with an open lung biopsy(6 patients) and furfilling the ATS criteria(7 patients) between March 1999 and October 2001 at the Gachon medical center, were enrolled in this study. Of these patients, eight patients were treated with a regimen including AGIIRA(AT group), and five were treated without AGIIRA(NT group). The pulmonary function tests and dyspnea(ATS scale) were measured at diagnosis and 1 year after treatment. All the data was collected to analyze the therapeutic effect of AGIIRA on the patients with IPF. Results : The AT group contained 8 patients(M:F=4:4) and the NT group contained 5 patients(M:F=3:2). There was no significant difference in the serum angiotensin II level between the two groups(