Tuberculosis and Respiratory Diseases
- 제55권4호
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- Pages.388-394
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- 2003
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
폐암에서 혈중 Cytokeratin 8, 18, 19의 진단적 가치
Diagnostic Value of Serum Cytokeratin 8, 18 and 19 in Lung Cancer
- 최창민 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
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김우진
(서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 오진영 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 강영애 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 유철규 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
-
이춘택
(서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 김영환 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 한성구 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
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심영수
(서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소)
- Choi, Chang Min (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
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Kim, Woo Jin
(Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Oh, Jin Young (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Kang, Young Ae (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Yoo, Chul Gyu (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
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Lee, Choon Taek
(Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Kim, Young Whan (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Han, Sung Koo (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
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Shim, Young-Soo
(Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine)
- 발행 : 2003.10.30
초록
배 경 : 지금까지 폐암의 종양표지자로 알려진 것들 중에 최근에는 CK 19뿐만 아니라 폐암에서 많이 발견되는 CK 8, 18에 대해 특이적인 세가지 단클론항체를 이용한 면역방사선계수법(MonoTotal
Background : Monoclonal antibodies directed against well-known epitopes on cytokeratin (CK) 8, 18 and 19 (Monototal) have been used in the development of a new diagnostic tool for lung cancer. In the mid-1990s, CK 19 fragments (Cyfra 21-1) became popular and widely used for such diagnosis. This is the first study specifically designed to compare these two markers. Method : The serum levels of CK 8, 18 and 19 were measured using two-site monoclonal/polyclonal immunoradiometric assay kit in 57 healthy adults and 289 patients who were admitted to Seoul National University Hospital from May to September, 2002. The lung cancer group comprised 129 primary lung cancer patients; 116 with non-small cell lung cancer(NSCLC) and 13 with small cell lung cancer (SCLC). The control group comprised 160 non-malignant pulmonary lung disease patients and 57 healthy adults. A total of 166 twin Monototal and Cyfra 21-1 serum assays were obtained; 76 with lung cancer, 70 with non-malignant pulmonary lung disease and 20 healthy adults. Results : The mean serum value of Monototal was