Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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A Case of Acute Pancreatitis in a Neuroblastoma Patient after Retinoic Acid Therapy

신경모세포종 환아에서 레티노익산 치료 중 발생한 급성 췌장염 1례

  • Jeong, Yoo Jin (Department of Pediatrics, School of Medicine, Keimyung University) ;
  • Seo, Yeon Kyong (Department of Pediatrics, School of Medicine, Keimyung University) ;
  • Kim, Heung Sik (Department of Pediatrics, School of Medicine, Keimyung University) ;
  • Lee, Hee Jung (Department of Diagnostic Radiology, School of Medicine, Keimyung University)
  • 정유진 (계명대학교 의과대학 소아과학교실) ;
  • 서연경 (계명대학교 의과대학 소아과학교실) ;
  • 김흥식 (계명대학교 의과대학 소아과학교실) ;
  • 이희정 (계명대학교 의과대학 진단방사선학교실)
  • Received : 2003.07.11
  • Accepted : 2003.09.05
  • Published : 2003.11.15
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Abstract

Retinoic acid has been used successfully as a differentiating agent in acute promyelocytic leukemia and neuroblastoma. However, some adverse effects have been recognized, such as headaches, dry skin and retinoic acid syndrome, a life threatening acute cardiorespiratory disorder. Acute pancreatitis with hyperlipidemia has rarely been reported. We experienced a case of acute pancreatitis with hyperlipidemia in a neuroblastoma patient after retinoic acid therapy for 21 months. Although the patient was ordered nothing by mouth and total parenteral nutrition was administrated, she died of disseminated intravascular coagulopathy and pulmonary hemorrhage, possibly because of oral intake during her recovery period.

신경모세포종 환아에서 레티노익산 치료 중 급성 췌장염이 합병되어 사망한 1례를 경험하여 보고하는 바이다. 레티노익산을 사용하는 환아에서 췌장염을 예방하기 위해서는 지속적인 혈중 지방 수치 추적이 필요할 것으로 생각되고 치료 중 호전을 보이더라도 지속적인 감시와 관찰이 필요할 것으로 생각된다.

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