Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

The effects of polylactic/polyglycolic copolymer (PLA/PGA) membrane on the healing of 1-wall intrabony defects in beagle dogs

성견 1면 골 결손부에서 Polylactic/polyglycolic acid copolymer (PLA/PGA) 흡수성 차단막의 치주 조직 재생에 대한 연구

  • Kim, Sung-Koo (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University) ;
  • Hwang, Sung-Joon (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University) ;
  • Kim, Min-Kyoung (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University) ;
  • Kim, Chang-Sung (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University) ;
  • Lee, Doug-Youn (Brain Korea 21 Project for Medical Science, Department and Research Institute of Dental Biomaterials and Bioengineering, College of Denistry, Yonsei University) ;
  • Lee, Yong-Keun (Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University) ;
  • Cho, Kyoo-Sung (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University, Brain Korea 21 Project for Medical Science) ;
  • Chai, Jung-Kiu (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University, Brain Korea 21 Project for Medical Science) ;
  • Choi, Seong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University, Brain Korea 21 Project for Medical Science)
  • 김성구 (연세대학교 치과대학 치주과학교실, 구강과학 연구소) ;
  • 황성준 (연세대학교 치과대학 치주과학교실, 구강과학 연구소) ;
  • 김민경 (연세대학교 치과대학 치주과학교실, 구강과학 연구소) ;
  • 김창성 (연세대학교 치과대학 치주과학교실, 구강과학 연구소) ;
  • 이덕연 (BK21 의과학 사업단, 연세대학교 치과대학 치과생체재료학교실) ;
  • 이용근 (연세대학교 치과대학 치과생체재료학교실) ;
  • 조규성 (연세대학교 치과대학 치주과학교실, 구강과학 연구소, BK21 의과학 사업단) ;
  • 채중규 (연세대학교 치과대학 치주과학교실, 구강과학 연구소) ;
  • 김종관 (연세대학교 치과대학 치주과학교실, 구강과학 연구소, BK21 의과학 사업단) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 구강과학 연구소, BK21 의과학 사업단)
  • Published : 2003.12.31
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Abstract

The goal of periodontal treatment is regeneration of the periodontium. Bone graft and absorbable PLA/PGA membrane have been used for this purpose. In this study, 4${\times}$4mm 1-wall intrabony defects were surgically created bilaterally in the mandible of five male beagles. The control group went through a conventional flap operation, while the experimental group I was treated with absorbable PLA/PGA membranes only, group II was treated with absorbable membrane and calcium phosphate. The results are the following : 1. The defect height was 4.82${\pm}$0.45mm in the control group, 4.93${\pm}$0.79mm in the experimental I group, and 4.92${\pm}$0.62mm in the experimental II group. There was no statistically significant difference among 3 groups(P <0.05). 2. The amount of junctional epithelium migration was 30.90${\pm}$9.92% of the defect height in the control group, 39.16${\pm}$7.51% in the experimental I group, and 38.68${\pm}$12.22% in the experimental II group. There was no statistically significant difference among 3 groups(P <0.05). 3. The amount of connective tissue adhesion was 36.38${\pm}$9.03% in the control group, 14.73${\pm}$3.93% in experimental I group, and 27.87${\pm}$9.70% experimental II group. Experimental group I was a statistically significantly different from control group(P <0.05). 4. The amount of new cementum regeneration was 32.92${\pm}$10.51%, 50.04${\pm}$7.61%, and 39.62${\pm}$12.14% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05). 5. The amount of new alveolar bone regeneration was 27.24${\pm}$7.49%, 40.75${\pm}$8.03%, and 36.47${\pm}$15.11% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P <0.05). The results suggest that the use of PLA/PGA membrane in 1-wall intrabony defect of beagle dogs may promote periodontal regeneration. Further studies are required to determine their regeneration effects.

Keywords

References

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