Diagnostic Criteria to Differentiate Medial Meniscal Injury from Degenerative Changes on $^{99m}Tc-MDP$ Knee SPECT in Patients with Chronic Knee Pain

만성 무릎관절 통증환자에서 내측 반월상연골 손상과 관절 퇴행성 변화의 감별을 위한 $^{99m}Tc-MDP$ 무릎관절 SPECT의 진단기준

  • Paeng, Jin-Chul (Departments of Nuclear Medicine Seoul national University College of Medicine) ;
  • Chung, June-Key (Departments of Nuclear Medicine Seoul national University College of Medicine) ;
  • Jeong, Hwan-Jeong (Department of Nuclear Medicine, Wonkwang University, College of Medicine) ;
  • Yoo, Jae-Ho (Departments of Orthopedic Surgery Seoul national University College of Medicine) ;
  • Kang, Won-Jun (Departments of Nuclear Medicine Seoul national University College of Medicine) ;
  • So, Young (Departments of Nuclear Medicine Seoul national University College of Medicine) ;
  • Lee, Dong-Soo (Departments of Nuclear Medicine Seoul national University College of Medicine) ;
  • Lee, Myung-Chul (Departments of Orthopedic Surgery Seoul national University College of Medicine) ;
  • Seong, Sang-Cheol (Departments of Orthopedic Surgery Seoul national University College of Medicine) ;
  • Lee, Myung-Chul (Departments of Nuclear Medicine Seoul national University College of Medicine)
  • 팽진철 (서울대학교의과대학 핵의학교실) ;
  • 정준기 (서울대학교의과대학 핵의학교실) ;
  • 정환정 (원광대학교의과대학 핵의학교실) ;
  • 유재호 (서울대학교의과대학 정형외과학교실) ;
  • 강원준 (서울대학교의과대학 핵의학교실) ;
  • 소영 (서울대학교의과대학 핵의학교실) ;
  • 이동수 (서울대학교의과대학 핵의학교실) ;
  • 이명철 (서울대학교의과대학 정형외과학교실) ;
  • 성상철 (서울대학교의과대학 정형외과학교실) ;
  • 이명철 (서울대학교의과대학 핵의학교실)
  • Published : 2003.04.30

Abstract

Purpose: In patients with chronic knee pain, the diagnostic performance of $^{99m}Tc-MDP$ knee SPECT for internal derangement of knee is deteriorated due to degenerative changes. In this study, we tried to establish diagnostic criteria to differentiate medial meniscal injury (MMI) from degenerative change (DC) when the uptake is increased in medial compartment. Materials and Methods: A total of 49 knee SPECT of the patients with chronic (more than 3 months) knee pain, which showed increased $^{99m}Tc-MDP$ uptake in the medial compartment, were included in this study. The diagnosis was confirmed by arthroscopy. On knee SPECT, 3 diagnosic criteria for MMI were investigated. In Criterion I, MMI was diagnosed when crescentic uptake was observed in the medial tibial plateau. In Criterion II, crescentic uptake was further classified into anterior, mid, posterior, and diffuse patterns, according to the location of maximal uptake; and only crescentic mid, posterior, and diffuse patterns were diagnosed as MMI. In Criterion III, MMI was diagnosed when medial tibial plateau showed higher activity then medial femoral condyle. The diagnostic performance of the 3 criteria was compared. Results: The sensitivity and specificity were 93% and 14% in Criterion I, 89% and 38% in Criterion II, and 75% and 67% in Criterion III, respectively. Criterion III had significantly improved diagnostic performance, especially, specificity. Conclusion: In this study, we established a practical diagnostic criterion to differentiate MMI from DC on knee SPECT. The result is helpful to improve the diagnostic value of knee SPECT as a screening test for chronic knee pain.

목적: 만성 무릎관절 통증환자에서 관절의 퇴행성 변화로 인하여 $^{99m}Tc-MDP$ SPECT를 이용한 관절내 장애의 진단성능이 떨어지게 된다. 이 연구에서는 내측 구획의 섭취 증가가 관찰될 때 이를 내측 반월상연골 손상(MMI)과 퇴행성 변화(DC)로 감별 진단하기 위한 진단기준을 찾고자 하였다. 대상 및 방법: 3개월 이상의 만성 통증으로 무릎관절 SPECT를 시행하고 이후 관절경 검사를 통해 관절 병소의 확진을 받은 환자 중 SPECT 상 내측 구획에 섭취 증가를 보인 47명, 49예의 영상을 대상으로 하였다. SPECT 영상에서 내측 경골 고원부에 초승달 모양의 섭취가 관찰될 때 MMI로 진단하는 기준(진단기준 I), 초승달 모양 섭취 양상에 따라 전측, 중앙측, 후측 및 미만성으로 구분하고 이 중 중앙측, 후측, 미만성만을 MMI로 진단하는 기준(진단기준 II), 이에 더해 섭취의 정도를 등급화하여 내측 구획에서 대퇴골 부위보다 경골 고원부의 섭취가 더 높을 때만 MMI로 진단하는 기준(진단기준 III)의 세 가지 진단기준을 설정하고 이들의 진단성능을 비교하였다. 결과: MMI 진단의 예민도와 특이도가 진단기준 I에서 각각 93%, 14%, 진단기준 II에서 각각 89%, 38%, 진단기준 III에서 75%, 67%로 형태학적 기준과 섭취 정도에 의한 기준을 첨가할수록 진단성능이 향상되었다. 결론: 이 연구에서는 무릎관절 SPECT가 적용되는 실제 임상 적응증에 가까운 만성 무릎관절 통증에서, 퇴행성 변화와 관절 내 장애를 감별하는 향상된 진단기준을 제시하였다. 이를 통하여 선별검사로서 무릎관절 SPECT의 진단적 가치를 더욱 높일 것으로 기대된다.

Keywords

References

  1. Collier BD, Johnson RP,Carrera GF, Isitman AT, Veluvolu P, Knobel J, et al. Chronic knee pain assessed by SPECT: corrparison with other modalities. Radiology 1985;157:795-802
  2. Gupta SM, Foster CR, Kayani N. Usefulness of SPECT in the early detection of avascular necrosis of the knees. Gin Nucl MOO 1987;12:99-102
  3. Murray IP, Dixon J, Kohan L. SPECT for acute knee pain. Gin Nucl MOO 1990;15:828-40
  4. Ryan PJ, Taylor M, Grevitt M, Allen P, Shields J, Clarke SE, et al. Bone single-photon emission tomography in recent meniscal tears: an assessrrent of diagnostic criteria. Eur J Nucl MOO 1993;20:703-7
  5. Cook GJ, Ryan PJ, Oarke SE, Fogelman I. SPECT bone scintigraphy of anterior cruciate ligament injury. J Nucl MOO 1996;37:1353-6
  6. Ryan PJ, Reddy K, Fleetcroft I. A prospective comparison of clinical examination, MRI, bone SPECT, and arthroscopy to detect meniscal tears. Gin Nucl MOO 1998;23:803-6
  7. Ryan PJ. Bone SPECT of the knees. Nucl Med Comnun 2000;21:877-85
  8. So Y, Chung JK, Seong SC, Sohn YJ, Kang HS, Lee DS, et al. Usefulness of 99Tcm-MDP knee SPET for pre-arthroscopic evaluation of patients with intemal derangements of the knee. Nucl Med Commun 2000;21:103-9
  9. Even-Sapir E, Arbel R, Lennan R, Husser G, Livshitz G, Halperin N. Bone injury associated with anterior cruciate Iigarrcnt and meniscal tears: assessment with bone single photon emission computed tomography. Invest Radiol 2002;37:521-7
  10. Dandy DJ, Jackson RW Meniscectomy and chondromalacia of the femoral condyle. J Bone Joint Surg Am 1975;57: 1116-1119
  11. Lee IS, Park KI, Lim MA, Lee SW 99mTc-MDP scintigraphy in osteoarthritis of knee. Kor J Nucl Med 1986;20:45-52
  12. Chang HK, Won KS, Kim NH, Choi YJ, Yoo DR, Kim SY. A comparison of bone SPECT, MRI, and arthroscopy for the evaluation of chronic kneepain. Kor J Rheum 1999;6: 117-24
  13. Barrett JP Jr, Rashkoff E, Sima EC, Wilson A Correlation of roentgenographic patterns and clinical manifestations of symptomatic idiopathic osteoarthritis of the knee. Clin Orthop 1990;253: 179-83
  14. Resnick D. Diagnosis of bone and joint disorders. 3rd ed. Philadelphia: WB. Saunders; 1995. p.l334-49
  15. Coventry MB. Proximal tibial varus osteotomy for osteoarthritis of the lateral compartment of the knee. J Bone Joint Surg Am 1987;69:32-8