Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Acute Oral Toxicity of Paecilomyces sinclairii in Beagle Dogs

비글개에 대한 Paecilomyces sinclairii의 급성 경구독성에 관한 연구

  • 안미영 (농업과학기술원 잠사곤충부) ;
  • 강세찬 (성균관대학교 약학대학 독성학교실) ;
  • 정나진 (성균관대학교 약학대학 독성학교실) ;
  • 구현정 (성균관대학교 약학대학 독성학교실) ;
  • 곽승준 (성균관대학교 약학대학 독성학교실) ;
  • 유은정 (성균관대학교 약학대학 독성학교실) ;
  • 정진아 (성균관대학교 약학대학 독성학교실) ;
  • 고진경 (성균관대학교 약학대학 독성학교실) ;
  • 류강선 (농업과학기술원 잠사곤충부)
  • Published : 2003.09.01
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Abstract

The acute toxicity of Paecilomyces sinclairii was tested in beagle dogs. We daily examined clinical signs, body weights, and hematological/biochemical examinations for 14 days after administration of Paecilomyces sinclairii with different dose levels (0, 0.4, 2 and 10 g/kg). There were no clinical signs and no significant changes in hematological and biochemical analysis. These results showed that Paecilomyces sinclairii did not induce any remarkable acute toxic response and the $LD_{50}$ was greater than 10 g/kg in beagle dogs.

Keywords

References

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