약학회지 (YAKHAK HOEJI)

  • 제47권1호
  • /
  • Pages.52-55
  • /
  • 2003
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  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Streptozotocin 유발 당뇨 흰쥐에서 백삼 에탄올엑스와 IH-901의 항당뇨 작용 비교

Comparisons of Antidiabetic Activities between White Ginseng Ethanol Extract and IH-901 in Streptozotocin-Induced Diabetic Rats

  • 고성권 (중앙대학교 인삼산업연구센터) ;
  • 성종환 ((주) 일화 중앙연구소) ;
  • 최용의 (중앙대학교 인삼산업연구센터) ;
  • 이충렬 (중앙대학교 인삼산업연구센터) ;
  • 박경수 (경희대학교 약학대학) ;
  • 정성현 (경희대학교 약학대학)
  • 발행 : 2003.02.01
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초록

Antidiabetic activities of white ginseng 50％ ethanol extract (WGE) and IH901, an intestinal metabolite of ginsenoside R $b_1$, were compared in multiple low dose streptozotocin (STZ)-induced diabetic rats. WGE or IH901 were coadministered with STZ on Day 1 at dose of 100 and 300 mg or 10 and 30 mg, respectively, and continually administered for 16 days. STZ dissolved in citrate boner was injected intraperitoneally at dose of 20 mg/kg for 5 consecutive days. During the experiment, plasma glucose level and body weight were measured every 4$^{th}$ day. Amount of food and water intake were evaluated once a week and compared between groups. WGE and IH901 both significantly reduced the plasma glucose levels on Day 16 as compared with those of the diabetic control group. In the meantime, amount of food and water intake in WGE-and IH901-treated groups were significantly improved in a dose dependent fashion as compared with those of the diabetic control group. Taken together WGE and IH901 showed the comparable antidiabetic activities at the corresponding doses used in this experiment.

키워드

참고문헌

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