The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Alteration of Neural Activity and Effect of Yanggyuksanhwa-tang(Lianggesanhuo-tang) on Cerebral Ischemia of Aged BCAO Rats; [$^{14}C$]2-Deoxyglucose Autoradiography Study

노령 흰쥐의 뇌허혈 손상시 뇌대사활성의 변화 및 량격산화탕의 영향에 대한 [$^{14}C$2-Deoxyglucose Autoradiography 연구

  • Sohn, Cheol-Hoon (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Shin, Jung-Won (Department of Neuroscience, Graduate School of East-West Medical Science Kyung Hee University) ;
  • Sohn, Young-Joo (Department of Neuroscience, Graduate School of East-West Medical Science Kyung Hee University) ;
  • Jung, Hyuk-Sang (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Won, Ran (Department of Neuroscience, Graduate School of East-West Medical Science Kyung Hee University) ;
  • Sohn, Nak-Won (Department of Neuroscience, Graduate School of East-West Medical Science Kyung Hee University)
  • 손철훈 (경희대학교 한의과대학 해부학교실) ;
  • 신정원 (경희대학교 동서의학대학원 신경과학교실) ;
  • 손영주 (경희대학교 동서의학대학원 신경과학교실) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실) ;
  • 원란 (경희대학교 동서의학대학원 신경과학교실) ;
  • 손낙원 (경희대학교 동서의학대학원 신경과학교실)
  • Published : 2003.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : This study investigated the alteration of neural activity and effect of Yanggyuksanhwa-tang (Lianggesanhuo-tang) on cerebral ischemia of rats. Methods : Considering age-related impact on cerebral ischemia, aged rats (18 months old) were used for this study. Ischemic damage was induced by the transient occlusion of bilateral common carotid arteries (BCAO) with hypotension. Yanggyuksanhwa-tang (Lianggesanhuo-tang) was administered twice a day orally. Then alterations of neural activities in the brain of aged BCAO rats were measured by the [$^{14}C$]2-deoxyglucose autoradiography method. Results : The BCAO in aged rats led to significant decrease of neural activity in the whole brain. Treatment with Yanggyuksanhwa-tang (Lianggesanhuo-tang) significantly attenuated the decrease of neural activity in the whole brain following BCAO ischemia. Treatment significantly attenuated the decrease of neural activity in the CA1, CA2, CA3, dentate gyrus of the hippocampus, activated barrel, barrel cortex, somatosensory cortex, cingulate cortex, caudate putamen, and medial septal nucleus following BCAO in aged rats. Treatment with Yanggyuksanhwa-tang (Lianggesanhuo-tang) also significantly attenuated the decrease of neural activity in the anteroventral thalamic nucleus, ventral anterior thalamic nucleus, arcuate nucleus, posterior hypothalamic area, medial mammillary nucleus, lateral periaqueductal gray, dorsal raphe nucleus, interpeduncular nucleus, median raphe nucleus, and medial pontine nucleus. Conclusion : It can be suggested that Yanggyuksanhwa-tang (Lianggesanhuo-tang) has a neuroprotecuve effect on cerebral ischemia through the control of glucose metabolic rate and cerebral blood flow.

Keywords

References

  1. Brain Res Brain Res Rev v.34 no.1;2 CNS energy metabolism as related to function Ames A
  2. J Cereb Blood Flow Metab. v.17 no.12 Transient middle cerebral artery occlusion by intraluminal suture: I. Three-dimensional autoradiographic image-analysis of local cerebral glucose metabolism-blood flow interrelationships during ischemia and early recirculation Belayev L;Zhao W;Busto R;Ginsberg MD
  3. Phil Trans R Soc Lond v.B354 Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging Magistretti PJ;Pellerin L
  4. Ann Neurol. v.25 Stroke risk and age do not predict behavioral activation of brain blood flow Ewing JR;Brown GC;Gdowski JW;Simkins R;Levine SR;Welch KMA
  5. Neurology v.34 Cerebral blood flow changes in benign aging and cerebrovascular disease Shaw TG;Mortel KF;Meyer JS;Rogers RL;Hardenberg J;Cutaia MM
  6. Neurobiology of Aging v.21 Chronic cerebrovascular ischemia in aged rats: effects on brain metabolic capacity and behavior Cada A;de la Torre JC;Gonzalez-Lima F
  7. Nippon Ika Daigaku Zasshi v.64 no.5 Measurement of regional cerebral blood flow and glucose utilization in rat brain under chronic hypoperfusion conditions following bilateral carotid artery occlusion. Analyzed by autoradiographical methods Otori T;Katsumata T;Katayama Y;Terashi A
  8. 경희의대논문집 v.18 최근 우리나라 뇌졸중의 역학적 양상에 관한 연구 박재인;윤태영;최중명;박순영;유동순
  9. J Neurochem v.28 The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anethetized albino rat Sokoloff L;Reirich M;Kennedy C;Des Rosiers MH;Patlak CS;Pettigreco KD;Sakunada O;Shinoham MC
  10. Biol Pharm Bull v.19 no.4 Ginseng pretreatment protects against transient global cerebral ischemia in the rat: measurement of local cerebral glucose utilization by $[^{14}C]$deoxyglucose autoradiography Choi SR;Saji H;Iida Y;Magata Y;Yokoyama A
  11. 경희의학 v.12 no.2 한방병원 심계내과 입원 환자에 대한 임상연구 권도익;고창남;조기호;기영석;배형섭;이경섭
  12. 경희한의대논문집 v.7 凉膈散火湯의 효능에 관한 실험적 연구 김진성;송일병
  13. 한국전통의학지 v.9 no.2 십이미관중탕, 凉膈散火湯, 형방사백산이 백서의 혈압 및 국소 뇌혈류량에 미치는 영향 이기주;김경요
  14. 東醫壽世保元 이제마
  15. J Neurosci v.18 no.20 Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion Chan PH;Kawase M;Murakami K;Chen SF;Li Y;Calagui B;Reola L;Carlson E;Epstein CJ
  16. Brain Res. v.877 Effect of hypotension severity on hippocampal CA1 neurons in a rat global ischemia model Sugawara T;Kawase M;Lewen A;Noshita N;Gasche Y;Fujimura M;Chan PH
  17. Brain Res. v.816 Chronic inhibition of NOS does not prevent plasticity of rat somatosensory(S1) cortex following deafferentation Sohn NW;Greenberg JH;Hand CL
  18. 대한한의학회지 v.20 no.2 지주막하출혈에 의한 뇌기저동맥의 형태학적 변화에 미치는 凉膈散火湯의 효과 이동원;이원철
  19. 대한한의학회지 v.17 no.2 凉膈散火湯이 gold thioglucose로 유발된 백서의 비만증에 미치는 효과 박재형;김경요;전병훈
  20. 사상의학회지 v.3 no.1 소양인에 응용되는 凉膈散火湯이 백서의 당뇨병에 미치는 영향 홍성범;홍순용
  21. Stroke v.23 Computed tomography in prognostic stroke evaluation Rasmussen D;Kohler O;Worm-Petersen S;Blegvad N;Jacobsen HL;Bergmann I;Egelblad M;Friis M;Nielsen NT
  22. J Gerontol A Biol Sci Med Sci. v.55 no.3 Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia Kharlamov A;Kharlamov E;Armstrong DM
  23. Brain Res. v.925 Aging has a complex effect of a rat model of ischemic stroke Shapira S;Spir M;Wengier A;Grauer E;Kadar T
  24. Neurobiol Aging v.9 no.5;6 An animal model of human-type memory loss based on aging, lesion, forebrain ischemia, and drug studies with the rat Ordy JM;Thomas GJ;Volpe BT;Dunlap WP;Colombo PM
  25. Pharmacol Biochem Behav v.62 no.4 Specific behavioral effects related to age and cerebral ischemia in rats Andersen MB;Zimmer J;Sams-Dodd F
  26. J Cereb Blood Flow Metab v.19 no.4 Upregulation of MAP1B and MAP2 in the rat brain after middle cerebral artery occlusion: effect of age Popa-Wagner A;Schroder E;Schmoll H;Walker LC;Kessler C
  27. J Gerontol A Biol Sci Med Sci. v.50 no.5 Temporal profile of neurochemical recovery following injury by transient cerebral ischemia Waller SB;Nyberg P;Dietz NJ
  28. Exp Gerontol. v.33 no.7;8 Diffusion constraints and neuron-glia interaction during aging Sykova E;Mazel T;Simonova Z
  29. Stroke v.29 no.10 beta-Amyloid precursor protein and ss-amyloid peptide immunoreactivity in the rat brain after middle cerebral artery occlusion: effect of age Popa-Wagner A;Schroder E;Walker LC;Kessler C
  30. Stroke v.20 no.4 Age-dependent vulnerability of brain choline acetyltransferase activity to transient cerebral ischemia in rats Nyberg P;Waller S
  31. Neurosci Lett. v.28;223 no.3 Reduced cytochrome oxidase and memory dysfunction after chronic brain ischemia in aged rats de la Torre JC;Cada A;Nelson N;Davis G;Sutherland RJ;Gonzalez-Lima F
  32. Neurobiol Aging. v.7 no.1 Ischemia and aging brain. Studies on glucose and energy metabolism in rat cerebral cortex Hoyer S;Krier C
  33. J Gerontol v.19 no.3 Biologic plasticity of the aging brain Hoyer S
  34. Neurochem Res. v.22 no.1 Age-related ischemia in the brain following bilateral carotid artery occlusion-collateral blood flow and brain metabolism He Z;Ibayashi S;Sugimori H;Fujii K;Sadoshima S;Fujishima M
  35. J Hypertens v.9 no.7 Differential effects of aging on the heart rate and blood pressure influences of arterial baroreceptors in awake rats Ferrari AU;Daffonchio A;Albergati F;Mancia G
  36. Angiology v.47 no.5 Brain ischemia following bilateral carotid occlusion during development of hypertension in young spontaneously hypertensive rats-importance of morphologic changes of the arteries of the circle of Willis Kusuda K;Ibayashi S;Sadoshima S;Ishitsuka T;Fujishima M
  37. J Neurosurg v.94 no.3 Diminution of metabolism/blood flow uncoupling following traumatic brain injury in rats in response to high-dose human albumin treatment Ginsberg MD;Zhao W;Belayev L;Alonso OF;Liu Y;Loor JY;Busto R
  38. Neurol Res. v.21 no.7 Double-tracer autoradiographic study of protein synthesis and glucose consumption in rats with focal cerebral ischemia Christensen T;Balchen T;Bruhn T;Diemer NH
  39. Neurosci Lett. v.133 no.1 $[^3H]PK$ 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex Myers R;Manjil LG;Frackowiak RS;Cremer JE
  40. Neuroreport v.11 no.9 MRI of small human stroke shows reversible diffusion changes in subcortical gray matter Doege CA;Kerskens CM;Romero BI;Brunecker P;Junge-Hulsing J;Muller B;Villringer A