Biomedical Science Letters (대한의생명과학회지)
- Volume 9 Issue 3
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- Pages.145-150
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- 2003
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Mucosal Mast Cell Responses in the Small Intestine of C3H/HeN and BALB/c Mice Infected with Echinostoma hortense
- Ryang, Yong-Suk (Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University) ;
- Im, Jee-Aee (Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University) ;
- Kim, In-Sik (Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University) ;
- Kim, Keun-Ha (Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University, Yeeun 2nd Business Center)
- Published : 2003.09.01
Abstract
In the intestinal mucosa, mast cells are thought to be responsible for the expulsion of parasites. We investigated the relationship of worm expulsion and mast cells in C3H/HeN and BALB/c mice infected with Echinostoma hortense. In addition, we examined whether the worm recovery rate was associated with the strain of mice, and whether a toluidine stain and immunohistochemistry using the c-kit antibody was effective in the detection of mast cells. In order to investigate the mucosal immune response of C3H/HeN and BALB/c mice, each mouse was infected orally with 30 E. hortense metacercariae. Then, the number of mucosal mast cells and worm recovery rates was observed in experimentally infected mouse strains between 1 week and 8 weeks post infection (PI). Mucosal mast cells were increased in 3 weeks P.I. in C3H/HeN and BALB/c mice. On the other hand, only mucosal goblet cells and worm recovery rates correlated in C3H/HeN mice (P=0.0482). Worm recoveries in C3H/HeN mice were 65.7