Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
권호 표지

Exhaled Nitric Oxide(NO) Among Adult Male Workers

성인남성 근로자들의 호기중 일산화질소

  • Published : 2003.09.01
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Abstract

Nitric Oxide(NO) is produced in many organs of the body, including the lung and airways, and it is detectable in the exhaled air. The measurement of exhaled NO(eNO) provides a simple non-invasive means for measuring airway inflammation, such as asthma. We measured eNO among adult male workers to examine the distribution of eNO in healthy people and to find factors affecting eNO. We measured eNO in a sample of 921 adult workers who also performed lung function test and skin prick test. Exhaled NO was measured in a sitting posture without using a nose clip and NO free gas. NO was measured at three expiratory rates(l8; 42; 71 $m\ell$/sec) and the flow rate of 71 $m\ell$/sec was used in analysis. The average eNO concentration was 5.29 $\pm$ 2.98 ppb. The level increased with age but not significantly(P=0.0529). Exhaled NO showed positive relations to the height(P=0.0001), pollen 1 (P=0.0124), asthma history(P=0.0212), allergic rhinitis symptom(P=0.0302). Exhaled NO Concentration of smokers( 4.62 ppb) was significantly lower than that of nonsmokers(5.99 ppb; P<0.0001).

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References

  1. Landry，J. S. and Eidelman, D. Nitric oxide, oxidants, and asthma. RT international, spring, 19-24, 2001
  2. Lundberg, J. O. N. : Ariborne nitric oxide: Inflammatory marker and aerocrine messenger in man. Acta Physiologica Scandinavica, Supplementum, 633, 1996
  3. Lundberg, J. O. N., Weitzberg, E., Lundberg, J. M. and Alving, K. Nitric oxide in exhaled air. Eur. Respir J. , 9, 2671-2680 1996 https://doi.org/10.1183/09031936.96.09122671
  4. Gaston, B., Drazen, J. M., Loscalzo, J. and Stamler, J. S. The Biology of nitrogen oxides in the airways. AJRCCM, 149(2), 538-551, 1994
  5. Zapol, W. M. and Bloch, K. D. : Nitric oxide and the lung, Vol 98, Marcel Dekker Inc, New York, 1997
  6. Morris, N. H., Sooranna, S. R., Steer， P. J. and Warren, J. B.:The effect of the menstrual cycle on exhaled nitric oxide and urinary nitrate concentration. Eur. J.of Clinical Investigation 26, 481-484, 1996 https://doi.org/10.1046/j.1365-2362.1996.163311.x
  7. Lundberg, J. O. N., Lundberg, J. M., Alving, K. and Weitzberg, E. Nitric oxide and inflammation: The answer is blowing in the wind. Nature Medicine, 13(1), 30-31, 1997
  8. Kharitonov, S., Alving, I. and Barnes, P. J. : Exhaled and nasal nitric oxide measurements: recommendations Eur. Respir J., 10, 1683-1693, 1997 https://doi.org/10.1183/09031936.97.10071683
  9. American Thoracic Society.: Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children- 1999. AJRCCM, 160, 2104-2117, 1999
  10. Dillon, W. C., Hampl, V., Shultz, P. J., Rubins, J. B., and Archer, S. L. : Origins of breath nitric oxide in humans. Chest, 110, 930-29, 1996 https://doi.org/10.1378/chest.110.4.930
  11. Baraldi, E., Azzolin, N. M., Dario, C., Carra， S., Ongaro, R., Biban, P. and Zacchello, F.: Effect of atmospheric nitric oxide(NO) on measurements of exhaled NO in asthmatic children. Pediatric Pulmonology, 26, 30-34, 1998 https://doi.org/10.1002/(SICI)1099-0496(199807)26:1<30::AID-PPUL6>3.0.CO;2-M
  12. Franklin, P. J., Taplin, R. and Stick, S. M. : A community study of exhaled nitric oxide in healthy children. AJRCCM, 159(1), 69-73, 1999
  13. Salome, A. M., Roberts, A. M., Brown, N. J., Dermand, J., Marks, G. B. and Woolcock, A. J.: Exhaled nitric oxide measurements in a population sample of young adults. AJRCCM, 159(3), 911-916, 1999
  14. 하태규, 이선화, 김상섭, 백도명 : 한국인의 호기중 일산화질소의 농도. 국민보건연구소 연구논총, 12, 63-68, 2001
  15. Corradi, M., Pelizzoni, A., Majori, M., Cuomo, A., de'Munari, E. and Pesci, A. : Influence of atmospheric nitric oxide concentration on the measurement of nitric oxide in exhaled air. Thorax. 53, 673-676, 1998 https://doi.org/10.1136/thx.53.8.673
  16. Rubinstein, I., Boucher, M. R., Zamel, N., Fredberg, J. J. and Hoffstein, V. : Effect of mouthpiece, noseclips, and head position on airway area measured by acoustic reflections. J. Appl. Physiol, 63, 1469-1474, 1995
  17. Hogman, M., Stromberg, S., Schedin, U., Frostell, C., Hedenstierna. G. and Gustafsson. L. E. : Nitric oxide from the human respiratory tract efficiently quantified by standardized single breath measurements. Acta Physiol Scand, 159, 345-346, 1997 https://doi.org/10.1046/j.1365-201X.1997.00101.x
  18. Silkoff, P. E., Mccleam, P. A., Slutsky, A. S., Furlott, H. G., Hoffstein, E., Wakita，S., Chapman, K. R., Szalai, J. P. and Zamel, N.: Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. AJRCCM, 155, 260-267, 1997
  19. Hogman, M., Drca, N., Ehrstect, C. and Merilainen, P.: Exhaled nitric oxide partitioned into alveolar, lower airways and nasal contributions. Respir. Med. , 94, 985-991, 2000 https://doi.org/10.1053/rmed.2000.0872
  20. Jorres, R. A. Modelling the production of nitric oxide within the human airways. Eur. Respir. J., 16, 555-560, 2000 https://doi.org/10.1034/j.1399-3003.2000.016003555.x
  21. Lehtimaki, L., Kankaanranta, H., Saarelainen, S., Hahtola, P., Jarvenpaa, R., Koivula, T., Tuηanmaa，V. and Moilanen, E. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. AJRCCM, 163, 1557-1561 , 2001
  22. Pedroletti, C., Zetterquist, W., Nordvall, L. and Alving, K. : Evaluation of exhaled nitric oxide in schoolchildren at different exhalation flow rates pediatric res., 52(3), 393-398, 2002 https://doi.org/10.1203/00006450-200209000-00015
  23. Tsoukias, N. M. and George, S. C. : A two-compartment model of pulmonary nitric oxide exchange dynamics. The American Physiological Society, 8750-7587, 1998
  24. Artlich, A., Hagenah, J. U., Jonas, S., Ahrens, P. and Gortner, L.: Exhaled Nitric oxide in childhood asthma. Eur. J. Pediatr., 155, 698-701, 1996 https://doi.org/10.1007/BF01957156
  25. Baraldi, E., Azzolin, N. M., Cracco, A. and Zacchello. F. : Reference values of exhaled nitric oxide for healthy children 6-15 years old. Pediatric Pulmonology, 27, 54-58, 1999
  26. Tsang, K. W., Ip, S. K., Leung, R., Tipoe, G. L., Chan, S. L., Shum, I. H., Ip, M. S., Yan, C. Fung, P. C., Chan-Yeung, M. and Lam, W.: Exhaled nitric oxide of age, gender and body size. Lung, 179, 83- 91, 2001 https://doi.org/10.1007/s004080000050
  27. Deykin, A., Massaro, A. J., Drazen, J. M. and Israel, E.: Exhaled nitric oxide as a diagnostic test for asthma. AJRCCM, 165, 1597-1601, 2002