Correlations Among Speed of Sound, Broadband Ultrasonic Attenuation, Broadband Ultrasonic Reflection, and Bone Density in Bovine Cancellous Bone

  • Lee, Kang-Il (Acoustics Research Laboratory and BK21 Physics Research Division, Department of Physics, SungKyunKwan University) ;
  • Choi, Bok-Kyoungi (Global Environment Research Laboratory, Korea Ocean Research and Development Institute) ;
  • Yoon, Suk-Wang (Acoustics Research Laboratory and BK21 Physics Research Division, Department of Physics, SungKyunKwan University)
  • 발행 : 2003.06.01

초록

Correlations between acoustic properties and bone density have been investigated in bovine cancellous bone. Speed of sound (SOS), broadband ultrasonic attenuation (BUA), and broadband ultrasonic reflection (BUR) were measured in 10 defatted bovine cancellous bone specimens in vitro. SOS showed a significant correlation with the apparent density of the bone. A comparable correlation was observed between BUA and the apparent density. BUR was rather highly correlated with the apparent density. It was shown that BUR had a weak correlation with BUA and a significant correlation with SOS. This indicates that the parameter BUR can provide important information that may not be contained in BUA and SOS and, therefore, can be useful as an alternative diagnostic parameter of osteoporosis. As expected, a linear combination of all three ultrasonic parameters in a multiple regression model resulted in a significant improvement in predicting the apparent bone density.

키워드

참고문헌

  1. C. M. Langton, S. B. Palmer, and R. W. Porter, 'The measurement of broadband ultrasonic attenuation in cancellous bone,' Eng. Med., 13, 89-91, 1984 https://doi.org/10.1243/EMED_JOUR_1984_013_022_02
  2. R. Strelitzki and J. A. Evans, 'An investigation of the measurement of broadband ultrasonic attenuation in trabecular bone,' Ultrasonics, 34, 785-791, 1996 https://doi.org/10.1016/S0041-624X(96)00079-0
  3. S. Han, J. Medige, and I. Ziv, 'Combined models of ultrasound velocity and attenuation for predicting trabecular bone strength and mineral density,' Clin. Biomech, 11, 348-353, 1996 https://doi.org/10.1016/0268-0033(96)00026-5
  4. J. Toyras, H. Kroger, and J. S. Jurvelin, 'Bone properties as estimated by mineral density, ultrasound attenuation, and velocity,' Bone, 25, 725-731, 1999 https://doi.org/10.1016/S8756-3282(99)00221-5
  5. C. F. Njeh, D. Hans, T. Fuerst, C. C. Gluer, and H. K. Genant, Quantitative Ultrasound: Assessment of osteoporosis and bone status, Martin Dunitz, London, 1999
  6. S. R. Cummings et al., 'The study of osteoporotic fractures research group: Bone density at various sites for the prediction of hip fractures,' Lancef, 341, 72-75, 1993 https://doi.org/10.1016/0140-6736(93)92555-8
  7. D. Hans, P. Dargent-Molina, A. M. Schott, J. L. Sebert, C. Cormier, P. O. Kotzki, P. D. Delmas, J. M. Pouilles, G. Breart, and P. J. Meunier, 'Ultrasonographic heel measurements to predict hip fracture in elderly women: The EPIDOS prospective study,' Lancet, 348, 511-514, 1996 https://doi.org/10.1016/S0140-6736(95)11456-4
  8. M. Schott, S. Weill-Engerer, D. Hans, F. Duboeuf, P. D. Delmas, and P. J. Meunier, 'Ultrasound discriminates patients with hip fracture equally well as dual-energy x-ray absorptionmetry and independently of bone mineral density,' J. Bone Min. Res, 10, 243-249, 1995 https://doi.org/10.1002/jbmr.5650100210
  9. K. A. Wear, A. P. Stuber, and J. C. Reynolds, 'Relationships of ultrasonic backscatter with ultrasonic attenuation, sound speed and bone mineral density in human calcaneus,' Ultrasound Med. Biol, 26, 1311-1316, 2000 https://doi.org/10.1016/S0301-5629(00)00267-2
  10. K. A. Wear and D. W. Armstrong III,'Relationships among calcaneal backscatter, attenuation, sound speed, hip bone mineral density, and age in normal adult women,' J. Acoust. Soc. Am, 110, 573-578, 2001 https://doi.org/10.1121/1.1378343
  11. C. Roux, V. Roberjot, S. Kolta, R. Porcher, J. Fechtenbaum, and P. Laugier, 'Broadband ultrasound backscattering (BUB) measurements at the os calcis in osteoporosis,' J. Bone Min. Res, 14, S375, 1999
  12. K. A. Wear, 'Ultrasonic attenuation in human calcaneus from 0.2 to 1.7 MHz,' IEEE Trans, Ultrason, Ferroelectr Freq. Control, 48, 602-608, 2001 https://doi.org/10.1109/58.911743
  13. G. W. C, Kaye and T. H. Laby, Table of Physical and Chemical Constants, Longman, London, 1973
  14. S. Han, J. Y. Rho, and I. Ziv, 'Ultrasound velocity and broadband attenuation over a wide range of bone mineral density,' Osteoporosis Int. 6, 291-296, 1996
  15. L. Serpe and J. Y. Rho, 'The nonlinear transition period of broadband ultrasound attenuation as bone density varies,' J. Biomech, 29, 963-966, 1996 https://doi.org/10.1016/0021-9290(95)00146-8
  16. J. M. Alves, W. Xu, D. Lin, R. S. Stiffert, J. T. Ryaby, and J. J. Kaufman, 'Ultrasonic assessment of human and bovine trabecular bone: a comparison study,' IEEET rans, Biomed, Eng, 43, 249-258, 1996 https://doi.org/10.1109/10.486282
  17. P. H. F. Nicholson, M. J. Haddaway, and M. W. J.Davie, 'The dependence of ultrasonic properties on orientation in human vertebral bone,' Phys. Med. Biol, 39, 1013-1024, 1994 https://doi.org/10.1088/0031-9155/39/6/007
  18. P. Laugier, P. Droin, A. M. LavaI-Jeantet, and G. Berger, 'In vitro assessment of the relationship between acoustic properties and bone mass density of the calcaneus by comparison of ultrasound parametric imaging and quantitative computed tomography,' Bone, 20, 157-165, 1997 https://doi.org/10.1016/S8756-3282(96)00347-X
  19. K. I. Lee, H. S. Roh, and S. W. Yoon, 'Correlations between acoustic properties and bone density in bovine cancellous bone from 0.5 to 2 MHz,' J. Acoust. Soc. Am., 113, 2933-2938, 2003 https://doi.org/10.1121/1.1567733
  20. R. Strelitzki, J. A. Evans, and A. J. Clarke, 'The influence of porosity and pore size on the ultrasonic properties of bone investigated using a phantom material,' Osteoporosis Int., 7, 370-375, 1997 https://doi.org/10.1007/BF01623780