• Progress in Medical Physics
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• v.18 no.3
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• pp.172-178
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• 2007

An ultrasonic bone densitometer has been developed by measuring speed of sound signal transmitted and received on the skin, not through the horizontal axis but through the vertical one in tissue. The SOS(speed of sound) method measuring the time difference between the ultrasound signals reflected from the both sides of surface of bone could produce more precise result compared with the BUA(broadband ultrasound attenuation) method measuring the frequency difference. Middle finger is selected to be the best measurement position in order to increase the accuracy, after due consideration that the thickness of flesh at the down part of thumb shows too much variation although the ratio of the receiving signal is higher than the other fingers. The measured value by using SOS method shows almost the same result as compared with the conventional DEXA method.

• The Journal of the Acoustical Society of Korea
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• v.22 no.2E
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• pp.69-77
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• 2003

Correlations between acoustic properties and bone density have been investigated in bovine cancellous bone. Speed of sound (SOS), broadband ultrasonic attenuation (BUA), and broadband ultrasonic reflection (BUR) were measured in 10 defatted bovine cancellous bone specimens in vitro. SOS showed a significant correlation with the apparent density of the bone. A comparable correlation was observed between BUA and the apparent density. BUR was rather highly correlated with the apparent density. It was shown that BUR had a weak correlation with BUA and a significant correlation with SOS. This indicates that the parameter BUR can provide important information that may not be contained in BUA and SOS and, therefore, can be useful as an alternative diagnostic parameter of osteoporosis. As expected, a linear combination of all three ultrasonic parameters in a multiple regression model resulted in a significant improvement in predicting the apparent bone density.

• Journal of the Korean Society for Nondestructive Testing
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• v.30 no.3
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• pp.207-211
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• 2010

In this paper, the fluid AID(acoustic inspection device) was developed to measure SOS(speed of sound) since fluids used in most of industrial fields have different properties and its equipment is highly expensive. From AID developed, it is intended to get potentially the capability to distinguish the kind of fluid using the measurement by the SOS at various fields. In order to measure the sound speed of specific fluids, the measurement system and ultrasonic sensors are composed. The fluid used in the experimental work are soybean oil, glycerin, diesel oil and the error of time difference due to the container wall is extracted for preliminary experiment. As results, the variations of sound speed according to the temperature change of target fluid were analyzed and the polynomial equations were proposed.

• BMB Reports
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• v.47 no.6
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• pp.348-353
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• 2014

The speed of sound (SOS) value is an indicator of bone mineral density (BMD). Previous genome-wide association (GWA) studies have identified a number of genes, whose variations may affect BMD levels. However, their biological implications have been elusive. We re-analyzed the GWA study dataset for the SOS values in skeletal sites of 4,659 Korean women, using a gene-set analysis software, GSA-SNP. We identified 10 common representative GO terms, and 17 candidate genes between these two traits (PGS < 0.05). Implication of these GO terms and genes in the bone mechanism is well supported by the literature survey. Interestingly, the significance levels of some member genes were inversely related, in several gene-sets that were shared between two skeletal sites. This implies that biological process, rather than SNP or gene, is the substantial unit of genetic association for SOS in bone. In conclusion, our findings may provide new insights into the biological mechanisms for BMD.

• Journal of radiological science and technology
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• v.41 no.1
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• pp.53-60
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• 2018

The purpose of this study was investigating the effect of 3D printing technology that changes the speed of sound (SOS) and the broadband ultrasound attenuation (BUA) by controlling the density of the media phantom. We used 3D printers which called additive manufacturing (AM) by using material with polylactic acid (PLA). The inside of the medium phantom was filled crossly with 100%, 90%, 80%, 70%, 60%, and 50% of the material. The ultrasonic instrument measured the SOS and the BUA using a 0.55 MHz ultrasound output in opposing mode with a pair of transducers. As a result, the density of the medium phantoms with the SOS showed very high correlation (r = 0.944), but the SOS showed very low correlation (r = 0.500). It is expecting that the manufacturing and measurement method of the medium phantom using 3D printing technology will be used as basic data for ultrasonic bone mineral density.

• Journal of the Korean Society for Nondestructive Testing
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• v.32 no.5
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• pp.502-508
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• 2012

Quantitative ultrasound technologies for osteoporosis diagnosis measure ultrasonic parameters such as speed of sound(SOS) and normalized broadband ultrasound attenuation(nBUA) in the calcaneus (heel bone). In the present study, the dependences of SOS and nBUA on bone mineral density in the proximal femur with high risk of fracture were investigated by using 20 trabecular bone samples extracted from bovine femurs. SOS and nBUA in the femoral trabecular bone samples were measured by using a transverse transmission method with one matched pair of ultrasonic transducers with a center frequency of 1.0 MHz. SOS and nBUA measured in the 20 trabecular bone samples exhibited high Pearson's correlation coefficients (r) of r = 0.83 and 0.72 with apparent bone density, respectively. The multiple regression analysis with SOS and nBUA as independent variables and apparent bone density as a dependent variable showed that the correlation coefficient r = 0.85 of the multiple linear regression model was higher than those of the simple linear regression model with either parameter SOS or nBUA as an independent variable. These high linear correlations between the ultrasonic parameters and the bone density suggest that the ultrasonic parameters measured in the femur can be useful for predicting the femoral bone mineral density.

• The Journal of the Acoustical Society of Korea
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• v.28 no.6
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• pp.542-547
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• 2009

In this in vivo study, correlations of lumbar and femoral bone mineral densities (BMDs) with calcaneal speed of sound (SOS) were investigated in 36 osteoporotic women. Areal BMDs of the L2-L4 lumbar spine and the right femoral neck were measured by using dual energy X-ray absorptiometry (DEXA). SOS of the right calcaneus was measured by using ultrasound bone densitometry. Pearson's correlation coefficient (r) and level of significance (p) were used to evaluate the correlations between measurements. Lumbar BMD was highly correlated with femoral BMD (r=0.81). Lumbar and femoral BMDs exhibited similar comparable negative correlations with age (r=-0.52 and r=-0.55). A moderate negative correlation was found between calcaneal SOS and age (r=-0.45). Calcaneal SOS was significantly correlated with lumbar and femoral BMDs, with a higher correlation with femoral BMD rather than with lumbar BMD (r=0.54 and r=0.62). However, calcaneal SOS may not be an optimum index for the estimation of BMD of the most important fracture sites, such as the lumbar and the femur, because it showed lower correlations with lumbar and femoral BMDs compared to that with calcaneal BMD. Therefore, the development of a quantitative ultrasound technology for the direct measurement of acoustic properties at the lumbar and the femur is required to estimate BMD of these sites more accurately.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.373-376
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• 2002

Most previous studies using ultrasound for osteoporosis diagnosis have employed ultrasound in a frequency range of 0.2-1 MHz. In this study, acoustic properties of the 12 defatted bovine cancellous bone specimens were investigated in vitro. Speed of sound (SOS) and broadband ultrasonic attenuation (BUA) were measured using three matched pairs of transducers with the center frequencies of 1, 2.25, and 3.5 MHz, respectively, in order to cover a broad frequency range of 0.5-2 MHz. The relative orientation between ultrasonic beam and bone specimens was the mediolateral (ML) direction of the bovine tibia. SOS showed significant linear positive correlations with apparent density for all three pairs of transducers of 1 MHz, 2.25 MHz, and 3.5 MHz, respectively. BUA showed relatively weak correlations with apparent density for the pairs of transducers of 1 MHz and 2.25 MHz. Furthermore, in the measurement with the pair of 3.5 MHz transducers, BUA was independent of apparent density. SOS and BUA were only weakly correlated with each other. The linear combination of SOS and BUA showed significant correlations with apparent density. These results suggest that the frequency range up to 1.5 MHz may be also useful in the osteoporosis diagnosis.

• Journal of Preventive Medicine and Public Health
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• v.34 no.4
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• pp.408-416
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• 2001

Objectives : To evaluate the diagnostic value of quantitative ultrasound (QUS) in the prediction of osteoporosis as defined by dual energy x-ray absorptiometry (DEXA) in postmenopausal women. Methods : Questionnaires and height and weight measurements were used in the investigation of 176 postmenopausal women. QUS measurements were taken on the right calcaneus while bone mineral density (BMD) measurements of the lumbar spine and femoral neck were made with DEXA. The areas under the curves (AUC) of the speed of sound (SOS) for osteoporosis in the lumbar spine and femoral neck were obtained through receiver operating characteristic (ROC) analysis and evaluated. A comparison was made, for osteoporosis in the lumbar spine and femoral neck, between the AUCs of the logistic model with clinical risk factors and SOS. Results : Pearson's correlation coefficients of SOS and lumbar spine BMD, and of SOS and femoral neck BMD were 0.26 and 0.37. The AUC for the logistic model in its discrimination for lumbar spine osteoporosis was 0.764, and for SOS 0.605. The AUCs for the logistic model in its discrimination for femoral neck osteoporosis and for SOS were 0.890 and 0.892, respectively. Conclusions : These results suggest that the diagnostic value of QUS as a screening tool for osteoporosis is moderate for the femoral neck, but merely low for the lumbar spine and that the predictability provided by SOS is no better than that by the sole use of clinical risk factors in postmenopausal women.

• Journal of Nutrition and Health
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• v.39 no.2
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• pp.171-183
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• 2006

This study was conducted to examine dietary factors affecting bone status in the rural aged men. Quantitative ultrasound measurements (QUS) of bone, that may reflect certain architectural aspects of bone, have been shown to be associated with bone mineral density and fracture. Information of diet and anthropometry was collected in 164 aged men. Dietary intake data were obtained by 24-hour recall method. Measurements of the speed of sound (SOS, m/s), at distal radius, mid-tibia, phalanx, were performed using Omnisense 7000S analyzer (Sunlight Ltd., Tel Aviv, Israel). T-scores for bone SOS measurements at distal radius, mid-tibia and phalanx were 0.60, 0.03 and -0.42 respectively. The prevalence of osteopenia by use of the WHO criteria was 17.7% at the mid-tibia and 25.3% of the subjects at the distal radius. Age were negative association with bone SOS at three sites. Osteopenia group of radius were significantly lower in total foods and vegetable intakes than normal group. After adjusted for age, vegetable intakes were significantly and positively related to bone SOS at the radius. The bone SOS of the tibia were significantly and positively related to vegetable protein, iron, folate and vegetable intakes, but negatively related to fat intakes. Multiple regression analysis showed that bone SOS of tibia was positively associated with folate intakes. Vegetable intakes were positively associated with the bone SOS at three sites. These results indicate that the consumption of vegetables, sources of folate, may have a effect on bone status of men.