Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Experimental infection in guinea pig with foot and mouth disease virus

  • Abdul-Ahad (Sylhet Government Veterinary College) ;
  • Rahman, Md-Siddiqur (Department of Medicine, Faculty of Veterinary Sciences, Bangladesh Agricultural University) ;
  • Rahman, Md-Mostafizur (Department of Microbiology & Hygiene, Faculty of Veterinary Sciences, Bangladesh Agricultural University) ;
  • Baek, Byeong-Kirl (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University) ;
  • Lee, John-Hwa (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University)
  • Published : 2003.03.01
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Abstract

In order to obtain information on murine model for foot and mouth disease virus(FMDV) type Asia 1, we studied whether guinea pig was a suitable model for studying FMDV. Apparently healthy 3 months old albino guinea pigs and unweaned 3 days old Swiss albino mice were used for this study. Total of 8 guinea pigs were divided into the infected(n=5) and control(n=3) groups. The incubation period of FMDV in the guinea pigs were roughly 2 days and the viremia persisted for 3 days in the guinea pigs. Mice inoculated with the plasma from control guinea pigs did not show any sign of viremia. The plasma were titrated by virus neutralization test using suckling mice as an indicator host. The mean virus neutralizing antibody titers of infected guinea pig at 3 DPI, 4 DPI and 5 DPI were log$\_$10/2.16, log$\_$10/ 3.39 and log$\_$10/ 3.44, respectively whereas there was no neutralizing antibody titer in control group. The difference between the mortality pattern and mean virus neutralizing antibody titer of infected and that of control group at day 3, 4, 5 were statistically significant(p<0.0l).

Keywords

References

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