정보처리학회논문지D (The KIPS Transactions:PartD)

한국정보처리학회 (Korea Information Processing Society)
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모티프 자원 통합을 이용한 단백질 모티프 예측 시스템 구현

Implementation of Protein Motif Prediction System Using integrated Motif Resources

  • 이범주 (충북대학교 대학원 전자계산학과) ;
  • 최은선 (충북대학교 대학원 전자계산학과) ;
  • 류근호 (충북대학교 전기전자 및 컴퓨터공학과)
  • 발행 : 2003.08.01
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⟨ 이전 논문 다음 논문 ⟩

초록

지놈 서열 시퀀싱을 통해 생성되는 원시 데이터에 대한 단백질 기능 및 구조 예측에 사용되는 모티프 데이터베이스들은 원시 데이터들의 폭발적인 성장추세에 맞추어 그 사용빈도가 증가하고 있다. 그러나 이러한 모티프 데이터베이스들은 독자적으로 개발, 발전하여왔고 웹 기반 cross-reference를 이용한 논리적 통합을 추진하여왔기 때문에 이질적인 검색 결과와 복잡한 질의 처리 문제, 중복된 데이터베이스 엔트리 핸들링 문제 등을 갖고 있다. 따라서, 이 논문에서는 이런 문제점들을 개선하기 위하여 물리적인 모티프 자원 통합을 제안하고, 패밀리 기반 단백질 예측 메소드들에 대한 통합 검색 방법을 기술한다. 끝으로 모티프 통합 데이터베이스 구축 및 단백질 모티프 예측 시스템 구현을 통한 결과를 평가한다.

Motif databases are used in the function and structure prediction of proteins which appear on new and rapid release of raw data from genome sequencing projects. Recently, the frequency of use about these databases increases continuously. However, existing motif databases were developed and extended independently and were integrated mainly by using a web-based cross-reference, thus these databases have a heterogeneous search result problem, a complex query process problem and a duplicate database entry handling problem. Therefore, in this paper, we suppose physical motif resource integration and describe the integrated search method about a family-based protein prediction for solving above these problems. Finally, we estimate our implementation of the motif integration database and prediction system for predicting protein motifs.

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