Osteosarcoma of the Proximal Humerus in a Dog

개의 상완골 근위단에 발생한 골육종

  • 김정은 (경북대학교 수의과대학) ;
  • 엄기동 (경북대학교 수의과대학) ;
  • 배재성 (경북대학교 수의과대학) ;
  • 강한샘 (경북대학교 수의과대학) ;
  • 이문학 (경북대학교 수의과대학) ;
  • 이해운 (경북대학교 수의과대학) ;
  • 성윤상 (경북대학교 수의과대학) ;
  • 이정민 (경북대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학)
  • Published : 2003.06.01

Abstract

A 13-year old male dog with right forelimb lameness, invisible swelling, anorexia and mild depression was referred to Veterinary leaching Hospital, College of Veterinary Medicine, Kyungpook National University. On forelimb radiographic views, periosteal and endosteal proliferation and cortical lysis and extremely aggressive and amorphous periosteal reactions were located along the metaphyseal region of the proximal humerus. Cytologic and histopathologic examinations after amputation showed anaplastic mesenchymal cells that produced osteoid changes, poorly differentiated osteoblast and osteoclast. And also, it included the neoplastic cells with large nucleoli, multiple nucleoli that differ in size and cytoplasm with several clear vacuoles. Based on the physical examination and laboratory, radiolographic, cytologic and histopathologic findings, this case was diagnosed as osteosarcoma of the proximal humerus.

Keywords

References

  1. J Am Vet Med Assoc v.200 Treatment of dogs with osteosarcoma by administration of cisplatin after amputation or limb-sparing surgery:22 cases(1987-1990) Berg,J.;Weinstein,M.J.;Schelling,S.H.;Rand,W.M.
  2. J Am Vet Med Assoc v.168 Results of surgical treatment in 65dogs with osteosarcoma Brodey,R.S.;Abt,D.A.
  3. Am J Vet Res v.39 High-dose methotrexate and leucovorin rescue in dogs with osteogenic sarcoma Cotter,S.M.;Parker,L.M.
  4. Small animal clinical oncology(3rd ed.) Tumors of the skeletal system Dornell,W.S.;Straw,R.C.;Withrow,S.J.
  5. J Am Vet Med Assoc v.179 Bone sarcomas associated with multifocal medullary bone infarction in dogs Dubielzig,R.R.;Biery,D.N.;Brodey,R.S.
  6. Small animal surgery(2nd ed.) Other diseases of bones and joints Hedlund,C.S.;Hulse,D.A.;Johnson,A.L.;Seim,H.B.;Willard,M.D.;Carroll,G.L.
  7. Vet Surg v.21 Canine axial skeletal osteosarcoma: A retrospective study of 116 cases(1986-1989) Heyman,S.J.;Diefenderfer,D.L.;Goldschmidt,M.H.;Newton,C.D. https://doi.org/10.1111/j.1532-950X.1992.tb00069.x
  8. J Am Anim Hosp Assoc v.34 Extraskeletal osteosarcomas in dogs:A retrospective study of 169 cases(1986-1996) Langenbadh,A.;Anderson,M.A.;Dambach,D.M.;Sorenmo,K.U.
  9. J Am Vet Med Assoc v.195 Limb-sparing treatment for osteosarcoma in dogs LaRue,S.M.;Withrow,S.J.;Powers,B.E.;Wrigley,G.H.;Gillette,E.L.;Schwarz,P.D.;Straw,R.C.;Richter,S.L.
  10. J Am Anim Hosp Assoc v.14 Osteosarcoma in dogs:A study of previous trauma, fracture and fracture fixation Knecht,C.D.;Priester,W.A.
  11. J Am Vet Med Assoc v.199 Osteogenic sarcoma and cisplatin chemotherapy in dogs: 16 cases(1986-1989) Kraegel,S.A.;Madewell,B.R.;Simonson,E.;Gregory,C.R.
  12. Vet Surg v.22 Resection of pulmonary metastasis in canine osteosarcoma:36 Cases(1983-1992) O'brien,M.G.;Straw,R.C.;Withrow,S.J.;Powers,B.E.;Jameson,V.J.;Lafferty,M.;Ogilvie,G.K.;LaRue,S.M. https://doi.org/10.1111/j.1532-950X.1993.tb01682.x
  13. J Am Vet Med Assoc v.202 Evaluation of single-agent chemotherapy for treatment of clinically evident osteosarcoma metastasis in dogs:45 cases(1987-1991) Ogilvie,G.K.;Strqw,R.C.;Jameson,V.J.;Walters,L.M.;Lafferty,M.H.;Powers,B.E.
  14. J Am Vet Med Assoc v.192 Use of cisplatin for treatment of appendicular osteosarcoma in dogs Shapiro,W.;Fossum,T.W.;Kitchell,B.E.;Couto,C.G.;Theilen,G.H.
  15. J Am Vet Med Assoc v.200 Prognosis for dogs with appendicular osteosarcoma treated by amputation alone:162 cases(1978-1988) Spodnick,G.J.;Berg,J.;Rand,W.M.;Schelling,S.H.;Couto,G.;Harvey,H.J.;Henderson,R.A.;MacEwen,G.;Mauldin,N.;McCaw,D.L.
  16. J Am Vet Med Assoc v.180 Fracture-associated sarcoma in the dog Steven,S.;Holm,R.B.;Pohler,O.E.M.;Fetter,A.W.;Olmscead,M.L.;Wind,A.P.
  17. J Am Vet Med Assoc v.200 Evaluation of survival times after limb amputation, with and without subsequent administration of cisplatin, for treatment of appendicular osteosarcoma in dogs: 30cases(1979-1990) Thompson,J.P.;Fugent,M.J.
  18. Texbook of veterinary diagnostic radiology(4th ed.) Bone tumors versus bone infections Thrall,D.E.