Advances in Traditional Medicine

  • 제3권4호
  • /
  • Pages.180-186
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  • 2003
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Antifilarial potential of the root extracts of Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi

  • Uddin, Qamar (Department of Chemistry, J.N. Medical College, Aligarh Muslim University) ;
  • Parveen, N. (Department of Chemistry, J.N. Medical College, Aligarh Muslim University) ;
  • Khan, Nizam U. (Department of Chemistry, J.N. Medical College, Aligarh Muslim University) ;
  • Zaidi, SM Kashif R. (Department of Biochemistry, Aligarh Muslim University) ;
  • Singhal, KC. (Department of Pharmacology, J.N. Medical College, Aligarh Muslim University)
  • 발행 : 2003.12.30
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초록

Effect of aqueous and alcoholic extracts of the roots of Mirabilis jalapa Linn. Four Oclock plant, on the spontaneous movements of both the whole worm and the nerve-muscle (n.m.) preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcoholic extract caused the inhibition of spontaneous movements of the whole worm and the n.m. preparation of S. cervi, whereas aqueous extract caused inhibition of spontaneous movements of the n.m. preparation. The initial stimulatory effect was not observed by aqueous and alcoholic extracts on n.m. preparation while effect of alcoholic extract on the whole worm was characterized by an increase in the amplitude of contractions followed by reversible paralysis. The concentrations required to inhibit the movements of the whole worm and n.m. preparation for alcoholic extract of root were $270\;{\mu}g/mL$ and $40\;{\mu}g/mL$, respectively whereas an aqueous extract caused inhibition of n.m. preparation at $30\;{\mu}g/mL$ suggesting a cuticular permeability barrier. Alcoholic extract of the roots of M. jalapa caused concentration related effect on the survival of microfilariae of S. cervi. The $LC_{50}$ and $LC_{90}$ for alcoholic extract as observed after 6 hrs. were found to be 10 ng/mL and 18 ng/mL., respectively.

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참고문헌

  1. Ahmad MS, Rauf A, Mustafa J, Osman SM. (1984) An 8-hydroxyoctadeca-cis-11, 14-dienoic acid from M. jalapa Seed oil. Phytochemistry 23, 2247.
  2. Begum S, Adil Q, Siddiqui BS, Siddiqui S. (1994) Triterpenes from Mirabilis jalapa. Fitroterapia 65, 77.
  3. Behari M, Andhiwal CK, Streible M. (1976) Some chemical constituents of the leaves M. jalapa L. Collect Czech Chern. Commun. 41, 295. https://doi.org/10.1135/cccc19760295
  4. Cammue BP, De Bolle MF, Terras FR, Proost P, Van Damme J, Rees SB, Vanderleyden J, Brockaert WF. (1992) Antimicrobial peptides from M. Jalapa L. Seeds. J. BioI. Chem. 267, 2228.
  5. Chopra RN, Nayar SL, Chopra IC. (1956) Glossary ofIndian medicinal plants. CSIR Publication, New Delhi,168.
  6. De Bolle MF, Osborn RW, Goderis IJ, Noe L, Acland D, Hart CA, Torrekens S, Van Leuvan F, Broekaert WF. (1996) Antimicrobial peptides from M. jalapa. Plant Mol. BioI. 31, 993. https://doi.org/10.1007/BF00040718
  7. Doepp H, Musso H. (1974) Fly agaric pigments. 4. Chromatographic analysis of betalain pigments of fly agarics and higher plants. Z. Naturforsch, Teil C 29, 640.
  8. Hawking F, Swewll P, Thurston JP. (1948) Mode of action of Hetrazan in filariasis. Lancet 2, 730.
  9. Maizles RM, Denham DA. (1992) Parasitology 105, 549.
  10. Martin RJ. (1982) ELectrophysiological effects of piperazine and diethylcarbamazine on Ascaris suum somatic muscle. Br. J. Pharmacol. 77, 255. https://doi.org/10.1111/j.1476-5381.1982.tb09294.x
  11. Pachauri, SP. (1972) "Cerebro-spinal nematodiasis" in a buffalo. A care report. Indian J. Anim. Res. 6, 17.
  12. Piatteli M, Minale L, Nicolaus RA. (1965) Pigments of Centrospermae. V. Betaxanthins from M. jalapa. Phytochemistry 4, 817. https://doi.org/10.1016/S0031-9422(00)86258-5
  13. Rastogi JN, Sharma OD, Loiwal SD. (1982) Amino acids in certain medicinal plants. Bull Pure Appl Sci. 1, 11.
  14. Ray B, Ghosal PK, Thakur S, Majumdar SG. (1988) Structural studies of a neutral polysaccharide from the roots bulb of M. jalapa. Carbohydrates Res. 176, 327.
  15. Saxena VK, Gupta HM. (1986) Chemical examination of seed of M. jalapa. Natt Acad Sci Lett. 9, 135.
  16. Siddiqui BS, Adil Q, Begum S, Siddiqui S. (1994) Terpenoids and Steroids of the aerial parts of M. jalapa Linn. Pak J Sci Ind Res. 37, 108.
  17. Singhal KC, Chandra O, Chawla SN, Gupta KP, Saxena PN. (1969) Setaria cervi a test organism for screening antifilarial agents in vitro. Jap. Pharm. Pharmacol. 21, 118. https://doi.org/10.1111/j.2042-7158.1969.tb08208.x
  18. Singhal KC, Madan BR, Saxena PN, Johri MBL. (1975) Effect of neurohumors and some other drugs on the movements of Setaria cervi. Indian J. Pharmacol. 7, 22.
  19. Singhal KC, Madan BR, Saxena PN. (1977) Effect of drugs on nerve-muscle complex of Setaria cervi. Indian J. Med. Res. 66, 517.
  20. Singhal KC, Madan BR, Saxena PN. (1978) Effect of diethylcarbamazine on Setaria cervi in vitro. Ind. J. Physiol. Pharmacol. 22, 93.
  21. Singhal KC, Saxena PN, Johri MBL. (1973) Studies on the use of Setaria cervi for in vitro antifilarial screenings. Jap. J. Pharmacol. 23, 793. https://doi.org/10.1254/jjp.23.793
  22. Singhal KC, Chandra, O, Saxena, PN. (1972) An in vitro method for the screening of antifilarial agent using Setaria cervi as test organism. Jap. J. Pharmacol. 22, 175. https://doi.org/10.1254/jjp.22.175
  23. The Wealth of India. (1962) The Dictionary of Indian raw materials and industrial products. CSIR Publication, New Delhi, Vol. VI, 392.
  24. Wajihullah. (2001) Comparative account of developing larvae of Setaria cervi and Diplotriaena tricuspis. J. Veterinary Parasit. 15, 117.
  25. Yang SW, Ubillas R, McAlpine J, Stafford A, Ecker DM, Talbol MK, Rogers B. (2001) Three new phenolics compounds from a manipulated plant cell culture, Mirabilis jalapa. J. Nat. Prod. 64, 313. https://doi.org/10.1021/np0004092