생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

조직배양산삼 부정근 메탄올 추출물이 식이성 고지혈증에 미치는 영향

Effect of the MeOH Extract of Adventious Root Culture of Panax ginseng on Hyperlipidemic Rat Induced by High Fat-rich Diet

  • 이은정 (서울대학교 천연물과학연구소) ;
  • 조해림 (서울대학교 천연물과학연구소) ;
  • 이대위 (서울대학교 천연물과학연구소) ;
  • 정춘식 (덕성여자대학교 약학대학) ;
  • 김종훈 (이우양행) ;
  • 김영식 (서울대학교 천연물과학연구소)
  • Lee, Eun-Jeong (Natural Product Research Institute, Seoul National University) ;
  • Zhao, Hai-Lin (Natural Product Research Institute, Seoul National University) ;
  • Li, Da-Wei (Natural Product Research Institute, Seoul National University) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University) ;
  • Kim, Jong-Hoon (EE WOO YANG HAENG Co. Ltd.) ;
  • Kim, Yeong-Shik (Natural Product Research Institute, Seoul National University)
  • 발행 : 2003.06.30
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초록

We have investigated the effect of MeOH extract of the adventious root culture of Panax ginseng on hyperlipidemic rats induced by fat-rich diet. We also analyzed and compared the content ginsenoisdes of the cultured ginsengs by HPLC. After oral administration of the MeOH extract to hyperlipidemic rats for four weeks, the variables including body weight, cholesterol, HDL, LDL, and triglyceride levels in serum were measured. One of the cultured ginseng roots (CBN3) decreased cholesterol and LDL-cholesterol and increased HDL-cholesterol levels in serum. HPLC analysis demonstrated that CBN3 contains more $Rb_1$ and Rd ginsenosides than any other cultured ginsengs and cultivated ginseng. These results suggest that CBN3 with high contents of $Rb_1$ and Rd may be useful in lowering blood cholesterol.

키워드

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