Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Pharmacological Screening of Sesbania grandiflora L. Poiret Extracts

  • Subramanian, E. Harihara (Department of Pharmaceutical Chemistry and Pharmacology, C. L. Baid Metha College of Pharmacy) ;
  • Varghese, Shyju (Department of Pharmaceutical Chemistry and Pharmacology, C. L. Baid Metha College of Pharmacy) ;
  • Rameshkumar, N. (Department of Pharmaceutical Chemistry and Pharmacology, C. L. Baid Metha College of Pharmacy) ;
  • Ilavarasan, R. (Department of Pharmaceutical Chemistry and Pharmacology, C. L. Baid Metha College of Pharmacy) ;
  • Sridhar, S.K. (Department of Pharmaceutical Chemistry and Pharmacology, C. L. Baid Metha College of Pharmacy)
  • Published : 2003.09.01
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Abstract

In the present study, the roots of Sesbania grandiflora L. Poiret (Papilionaceae) were successively extracted with petroleum ether (PE), chloroform (CE), methanol (ME) and water (AE) by soxhlet extraction. The extracts were vacuum dried and screened for analgesic, antidiarrhoeal, antibacterial (Staphylococcus epidermidis, Staphylococcus aureus, Micrococcus luteus, Bacillus cereus, and Klebsiella pneumonia) and antifungal (Candida albicans and Aspergillus niger) activity. All the extracts exhibited potent, dose dependant (40 and 80 mg/kg) and significant analgesic and antidiarrhoeal activity in the order of AE>PE>CE>ME and ME>PE>AE>CE respectively. AE at the experimental dose was found to exhibit more potent analgesic activity than standard drug. All the extracts exhibited significant antibacterial $(100\;{\mu}g/ml)$ and antifungal activity $(50\;and\;100\;{\mu}g/ml)$. ME exhibited the most potent antibacterial activity.

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