Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antinociceptive and Sedative Hypnotic effect of Artemisia pallens Wall

  • Karunanidhi, Natesan (Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Saravanan, Sampath (Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Vinothkumar, Vinothkumar (Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Selvamani, Selvamani (Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Ghosh, Shruti (Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Gupta, Jayanta Kumar (Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University)
  • Published : 2003.06.01
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Abstract

The present investigation was carried out to evaluate the antinociceptive and sedative - hypnotic effect of a vacuum dried methanol extract of aerial parts of Artemisia pallens. In the tail-flick method with Swiss albino mice the methanol extract at the doses of (1500 mg/kg, 2000 mg/kg, and 2500 mg/kg) showed significant antinociceptive activity. Significant potentiation of Pentobarbitone sodium - induced sleeping time was observed in mice on co-administration of the various doses of the methanol extract of Artemisia pallens.

Keywords

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