Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Hepatoprotective Activity of Medicinal Plant Extracts on Carbon Tetrachloride-induced Hepatotoxicity in Rats

  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University) ;
  • Suh, In-Ok (College of Pharmacy, Duksung Women's University) ;
  • Hyun, Jin-Ee (College of Pharmacy, Duksung Women's University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University)
  • Published : 2003.06.01
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Abstract

The purpose of this study was to find the effect of 36 traditional medicinal plant species on hepatoprotective activity screening. For this study, carbon tetrachloride $(CCl_{4})$ intoxificated rats were used. Test extracts were made with the traditional medicinal plants refluxed in 95% MeOH and orally administered to the rats. Sixteen species, such as Mentha arvensis, Sophora japonica, Benincasa hispida, Lonicera japonica (Lonicerae Flos), Agaricus blazei, Epimedium koreanum, Aralia continentalis, Lithospermum erythrorhizon, Cimicifuga foetida, Gastrodia elata, Sanguisorba officinalis, Cephalonoplos segetum, Bupleurum falcatum, Alisma plantago-aquatica var. orientale, Lonicera japonica (Lonicerae Folium) and Sinomenium acutum showed protective effect against increased serum alanine aminotransferase (ALT) and/or serum asparteate aminotransferase (AST) activities.

Keywords

References

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