The Korean Journal of Physiology and Pharmacology

  • 제7권6호
  • /
  • Pages.307-310
  • /
  • 2003
  • /
  • 1226-4512(pISSN)
  • /
  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
권호 표지

Curcumin Attenuates Gliall Cell Activation But Cannot Suppress Hippocampal CA3 Neuronal Cell Death in i.c.v. Kanic Acid Injection Model

  • Cho, Jae-Young (Department of Pharmacology, College of Medicine ,Medical Science Research Institute, Kangwon National University) ;
  • Kong, Pil-Jae (Department of Pharmacology, College of Medicine ,Medical Science Research Institute, Kangwon National University) ;
  • Chun, Wan-Joo (Department of Pharmacology, College of Medicine ,Medical Science Research Institute, Kangwon National University) ;
  • Moon, Yeo-Ok (Department of Pharmacology, College of Medicine ,Medical Science Research Institute, Kangwon National University) ;
  • Park, Yee-Tae (Department of Neuroscience, Medical Science Research Institute, Kangwon National University) ;
  • Lim, So-Young (Department of Anesthesiology, College of Medicine, Hallym University) ;
  • Kim, Sung-Soo (Department of Pharmacology, College of Medicine and Department of Neuroscience, Medical Science Research Institute, Kangwon National University)
  • 발행 : 2003.12.21
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Kainic acid (KA) is a structural analogue of glutamate that interacts with specific presynaptic and postsynaptic receptors to potentiate the release and excitatory actions of glutamate. Systemic or intracerebroventricular (i.c.v.) administration of KA to experimental animals elicits multifocal seizures with a predominantly limbic localization, and results in neuronal death of cornu ammonia 1 (CA1), reactive gliosis and biochemical changes in the hippocampus and other limbic structures. Several lines of evidence suggest that reactive oxygen species (ROS) play a pivotal role in the pathogenesis of excitotoxic death by KA. Curcumin has been known to possess anti-oxidative and anti-inflammatory activities. In this study, the effects of curcumin on KA induced hippocampal cell death, reactive gliosis and biochemical changes in reactive glia were investigated by immunohistochemical methods. Our data demonstrated that curcumin attenuated KA-induced astroglial and microglial activation although it did not protect KA-induced hippocampal cell death.

키워드

참고문헌

  1. Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med 57: 1－7, 1991 https://doi.org/10.1055/s-2006-960004
  2. Arvanitis DL, Stavridou AI, Mori de Moro G, Szuchet S. Reactive astrocytes upregulate one or more gene products that are recognized by monoclonal antibody H. Cell Tissue Res 304: 11－ 19, 2001 https://doi.org/10.1007/s004410100349
  3. Baker H, Farbman AI. Olfactory afferent regulation of the dopamine phenotype in the fetal rat olfactory system. Neuroscience 52: 115－134, 1993 https://doi.org/10.1016/0306-4522(93)90187-K
  4. Ben-Hur T, Cialic R, Itzik A, Barak O, Yirmiya R, Weidenfeld J. A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis. Neuroscience 108: 119－127, 2001 https://doi.org/10.1016/S0306-4522(01)00404-3
  5. Dehmer T, Lindenau J, Haid S, Dichgans J, Schulz JB. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem 74: 2213－2216, 2000 https://doi.org/10.1046/j.1471-4159.2000.0742213.x
  6. Giusti P, Lipartiti M, Franceschini D, Schiavo N, Floreani M, Manev H. Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. FASEB J 10: 891－896, 1996
  7. Gutierrez E, Huang Y, Haglid K, Bao F, Hansson HA, Hamberger A, Viano D. A new model for diffuse brain injury by rotational acceleration: I model, gross appearance, and astrocytosis. J Neurotrauma 18: 247－257, 2001 https://doi.org/10.1089/08977150151070874
  8. Izquierdo LA, Barros DM, Ardenghi PG, Pereira P, Rodrigues C, Choi H, Medina JH, Izquierdo I. Different hippocampal molecular requirements for short- and long-term retrieval of one-trial avoidance learning. Behav Brain Res 111: 93－98, 2000 https://doi.org/10.1016/S0166-4328(00)00137-6
  9. Iwase K, Miyanaka K, Shimizu A, Nagasaki A, Gotoh T, Mori M, Takiguchi M. Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment. J Biol Chem 275: 11929－11933, 2000 https://doi.org/10.1074/jbc.275.16.11929
  10. Kingham PJ, Cuzner ML, Pocock JM. Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. J Neurochem 73: 538－ 547, 1999 https://doi.org/10.1046/j.1471-4159.1999.0730538.x
  11. Kong GY, Kristensson K, Bentivoglio M. Reaction of mouse brain oligodendrocytes and their precursors, astrocytes and microglia, to proinflammatory mediators circulating in the cerebrospinal fluid. Glia 37: 191－205, 2002 https://doi.org/10.1002/glia.10030
  12. Laursen SE, Belknap JK. Intracerebroventricular injections in mice. Some methodological refinements. J Pharmacol Methods 16: 355－357, 1986 https://doi.org/10.1016/0160-5402(86)90038-0
  13. Lodha R, Bagga A. Traditional Indian systems of medicine. Ann Acad Med Singapore 29:37－41, 2000
  14. McGeer EG, McGeer PL. Brain inflammation in Alzheimer disease and the therapeutic implications. Curr Pharm Des 5: 821－836, 1999
  15. Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 28: 1303－1312, 2000 https://doi.org/10.1016/S0891-5849(00)00294-X
  16. Schipper HM, Bernier L, Mehindate K, Frankel D. Mitochondrial iron sequestration in dopamine-challenged astroglia: role of heme oxygenase-1 and the permeability transition pore. J Neurochem 72: 1802－1811, 1999 https://doi.org/10.1046/j.1471-4159.1999.0721802.x
  17. Sola C, Casal C, Tusell JM, Serratosa J. Astrocytes enhance lipopolysaccharide-induced nitric oxide production by microglial cells. Eur J Neurosci 16: 1275－1283, 2002 https://doi.org/10.1046/j.1460-9568.2002.02199.x
  18. Sperk G, Lassmann H, Baran H, Kish SJ, Seitelberger F, Hornykiewicz O. Kainic acid induced seizures: neurochemical and histopathological changes. Neuroscience 10: 1301－1315, 1983 https://doi.org/10.1016/0306-4522(83)90113-6
  19. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 480－481: 243－268, 2001 https://doi.org/10.1016/S0027-5107(01)00183-X
  20. Yoshida H, Imaizumi T, Kumagai M, Kimura K, Satoh C, Hanada N, Fujimoto K, Nishi N, Tanji K, Matsumiya T, Mori F, Cui XF, Tamo W, Shibata T, Takanashi S, Okumura K, Nakamura T, Wakabayashi K, Hirashima M, Sato Y, Satoh K. Interleukin- 1beta stimulates galectin-9 expression in human astrocytes. Neuroreport 12: 3755－3758, 2001 https://doi.org/10.1097/00001756-200112040-00030
  21. Zagulska-Szymczak S, Filipkowski RK, Kaczmarek L. Kainateinduced genes in the hippocampus: lessons from expression patterns. Neurochem Int 38: 485－501, 2001