Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Characterization and Modification of Low Molecular Water-Soluble Chitosan for Pharmaceutical Application

  • Jang, Mi-Kyeong (Department of Polymer Science & Engineering, Sunchon National University) ;
  • Nah, Jae-Woon (Department of Polymer Science & Engineering, Sunchon National University)
  • Published : 2003.09.20
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Abstract

The low molecular water-soluble chitosan nanoparticles (LMWSC-NPs) were prepared, which was modified with hydrophilic and hydrophobic moieties to evaluate the potential for pharmaceutics application. The synthesis of LMWSC-NPs was identified by FT-IR and $^1H$-NMR spectra. Also, we measured the photon correlation spectroscopy (PCS), transmission electron microscope (TEM) and atomic force microscope (AFM) to investigate the characteristics and morphology of the LMWSC-NPs. At the PCS measurement, the more increase the number of substitutive group, the more decrease the positive charge of LMWSC-NP surface. From the results of TEM and AFM, spherical morphologies were observed, and their sizes were 30-150 nm. Resultantly, LMWSC-NPs prepared in this experiment will be expected as a suitable device for the drug targeting system.

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