Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Chirospecific Synthesis of D-erythro- and L-threo-Sphinganines from Sugars

  • Jeong, Ill-Yun (Division of Applied Life Science (BK21 Program), Department of Agricultural Chemistry,Gyeongsang National University) ;
  • Lee, Jin-Hwan (Division of Applied Life Science (BK21 Program), Department of Agricultural Chemistry,Gyeongsang National University) ;
  • Lee, Byong-Won (Division of Applied Life Science (BK21 Program), Department of Agricultural Chemistry,Gyeongsang National University) ;
  • Kim, Jin-Hyo (Division of Applied Life Science (BK21 Program), Department of Agricultural Chemistry,Gyeongsang National University) ;
  • Park, Ki-Hun (Division of Applied Life Science (BK21 Program), Department of Agricultural Chemistry,Gyeongsang National University)
  • Published : 2003.05.20
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Abstract

D-erythro-sphinganine 1 and L-threo-sphinganine 2 have been prepared in the enantiomerically pure form by the chirospecific manner. Key intermediates, 2-amino-3-hydroxy-4-pentenoates 8 and 12, were obtained from L-glucono-1,5-lactone and L-gulonic acid g-lactone via a simultaneous dealkoxyhalogenation.

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References

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