Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Estimation for Retention Factor of Isoflavones in Physico-Chemical Properties

  • Lee, Seung-Ki (Center for Advanced Bioseparation Technology and Dept. of Chem. Eng., Inha University) ;
  • Row, Kyung-Ho (Center for Advanced Bioseparation Technology and Dept. of Chem. Eng., Inha University)
  • Published : 2003.09.20
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Abstract

The estimation of retention factors by correlation equations with physico-chmical properties maybe helpful in chromatographic work. The physico-chemical properties were water solubility (S), hydrophobicity (P), total energy ($E_t$), connectivity index 1 ($^1{\chi}$), hydrophilic-lipophlic balance (x) and hydrophilic surface area (h) of isoflavones. The retention factors were experimentally measured by RP-HPLC. Especially, the empirical regulations of water solubility and hydrophobicity were expressed in a linear form. The equation between retention factors and various physico-chemical properties of isoflavones was suggested as $k = a_0 + a_1\;log S + a_2log\;P^Q + a_3(E_t) + a_4(^1{\chi}) + a_5(x) + a_6(h)$, and the correlation coefficients estimated were relatively higher than 0.95. The empirical equations might be successfully used for a prediction of the various chromatographic characteristics of substances, with a similar chemical structure.

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