대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

황련(黃連)의 Helicobacter pylori에 대한 항균 효과

Antibacterial effects of Corptis japonica against Helicobacter pylori

  • 서운교 (동국대학교 한의과대학 내과학교실) ;
  • 신정인 (동국대학교 한의과대학 내과학교실)
  • Seo Un-Kyo (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Shin Jeong-In (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 발행 : 2003.06.01
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초록

Water and ethanol extracts of 67 species of medicinal plants were tested to determine antimicrobial activity against Helicobacter pylori. Among them, the extracts of Coptis japonica showed the best antibacterial activity. The extract of C. japonica showed four major spots on TLC plate and the Rf values of the spots were 0.07, 0.13, 0.21 and 0.73, respectively. Except for the spot of Rf 0.73, other three spots inhibited the cell growth of H. pylori. As shown in HPLC analysis, three antimicrobial spots contain berberine, major antimicrobial substance of C. japonica. However, the spot of Rf 0.13 had higher activity than berberine. The concentrated water extract of three prescribed medicines related with C. japonica showed good antibacterial activity against H. pylori.

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