Journal of the Korean Academy of Child and Adolescent Psychiatry
- Volume 13 Issue 1
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- Pages.76-84
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- 2002
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- 2233-9183(eISSN)
NORMOBARIC OXYGEN($O_2$ ) ADMINISTRATION EFFECT ON ATTENTION AND MEMORY FUNCTION IN TEENAGE ADOLESCENTS
10대 청소년의 주의력과 기억능력에 미치는 정상기압 산소흡입 효과
- Kim, Byung-Hyo (Department of Neuropsychiatry, Gyeongsang National University Hospital) ;
- Kim, Young-Mi (Department of Neuropsychiatry, Gyeongsang National University Hospital) ;
- Cho, Soo-Churl (Division of Child & Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital) ;
- Kim, Boong-Nyun (Division of Child & Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital)
- 김병효 (경상대학교병원 신경정신과) ;
- 김영미 (경상대학교병원 신경정신과) ;
- 조수철 (서울대학교병원 신경정신과(소아-청소년 정신과)) ;
- 김붕년 (서울대학교병원 신경정신과(소아-청소년 정신과))
- Published : 2002.12.31
Abstract
Objectives:This study was conducted to investigate the effect of oxygen on attention and memory functions in healthy adolescents. Methods:The participant subjects were recruited from local advertisement. All subjects are students attending ordinary middle and high school. Their degree of achievement was average or below average. Before the study, its nature and purpose were fully explained to the patients and their parents, and a written informed consent was obtained from each child's parent and a written assent from each child for entire the procedure. The Ethics Committee and Clinical Research Committee of Gyeongsang National University Hospital approved the protocol. For baseline assessment, all subjects received tests for attention and memory. All tests were conducted by a certified psychologist. Stroop test, continuous performance test and trail making test A and B were used for evaluation of attention. As memory tests, we used memory assessment scale(MAS), standardized memory assessment tools. Ten to fourteen days after initial assessments, same tests was applied to the same subjects after prior 5 minute oxygen inhalation. Results:1) Attention test:Improved performances in trail making part B, and stroop test were found in normobaric oxygen inhalation group compared to air inhalation group. Improved reaction time in those tests seemed to reflect the enhanced executive prefrontal activity. 2) Memory test:More words and digits memorization were found in short-term memory subscale score in MAS in oxygen inhalation group compared to air inhalation group. This finding suggested the improved working memory function after oxygen inhalation. Conclusion:Though interpreted cautiously, these results suggested that normobaric oxygen inhalation could enhance executive function and working memory of prefrontal lobe. Further study, however, should be performed to investigate the mechanism of effects of oxygen on cognitive enhancement.
목 적:독일의 신경심리학자인 Moss 등의 1996년에서 1999년까지의 일련의 연구들에서 정상기압의 산소공급 후 정상 성인에서의 기억능력이 뚜렷하게 호전된다는 보고가 있었다. 그러나 아직까지 10대 청소년을 대상으로 한 연구는 없는 상황이다. 이에, 본 연구팀에서는 새롭게 개발된 산소흡입장치(Oxygen administration device)를 가지고 산소흡입이 청소년의 인지능력 향상에 도움이 되는지를 알아보기 위해 실험집단-위약집단-이중맹검법으로 평가하였다. 방 법:14세에서 17세까지의 청소년 23명을 대상으로 하였다. 학급성적 백분위 20%이상 50%미만에 해당하는 중-고등학생들을 대상으로 하였고, 정신과전문의가 평가하여 특정한 정신병리가 없고, 실험에 자발적 참여의지를 보인 청소년만을 연구에 참여시켰다. 주의력평가를 위해 사용 한 검사는 스트룹(stroop) 검사와 선로잇기(trail-making)검사, 연속수행검사(continuous performance test)였고, 기억능력의 측정을 위해서는 표준화된 기억평가척도(Memory Assessment Scale:MAS)를 사용하였다. 23명의 청소년을 무작위 배정하여 12명은 주의력검사와 기억능력 검사 10분전에 5분에 걸쳐