Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Immunohistochemistry of Human Telomerase Reverse Transcriptase in Head and Neck Squamous Cell Carcinoma and Resection Margin

두경부 편평상피세포암과 절제연에서 Human Telomerase Reverse Transcriptase의 발현

  • Kim Yong-Bum (Department of Otolaryngology, College of Medicine, Kyung Hee University) ;
  • Rho Kyung-Sup (Department of Otolaryngology, College of Medicine, Kyung Hee University) ;
  • Hong Nam-Pyo (Department of Otolaryngology, College of Medicine, Kyung Hee University) ;
  • Ahn Hwoe-Young (Department of Otolaryngology, College of Medicine, Kyung Hee University) ;
  • Lee Yong-Sik (Department of Otolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Song Young-Ho (Department of Otolaryngology, College of Medicine, Kyung Hee University)
  • 김용범 (경희대학교 의과대학 부속병원 이비인후과학교실) ;
  • 노경섭 (경희대학교 의과대학 부속병원 이비인후과학교실) ;
  • 홍남표 (경희대학교 의과대학 부속병원 이비인후과학교실) ;
  • 안회영 (경희대학교 의과대학 부속병원 이비인후과학교실) ;
  • 이용식 (원자력병원 이비인후과학교실) ;
  • 송영호 (경희대학교 의과대학 부속병원 이비인후과학교실)
  • Published : 2002.05.01
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Abstract

Background and Objectives: The expression of telomerase, a ribonucleoprotein complex, has been detected in tissues from many human cancers, but not in the majority of normal tissues except germ cell. It is believed that the activation of telomerase is linked to celluar immortality and may playa role in tumorigenesis. Human telomerase reverse transcriptase (hTERT) has been identified as a putative catalytic subunit of human telomerase and its expression is closely correlated with telomease activity. We studied the expression of hTERT in head and neck squamous cell carcinoma (HNSCC) and resection margin by immunohistochemistry for hTERT and evaluate the correlation between hTERT expression and clinical data in HNSCC. Materials and Methods: We performed a immunohistochemistry in 17 cases of HNSCC and 10 cases of resection margins, histologically normal. The correlations between the hTERT expression and the clinical data in HNSCC were analyzed. Result: hTERT immunoreactivities were detected in 14 of 17 (82.4%) HNSCC, 1 of 10 (10%) resection margin. No correlation was observed between clinical data and hTERT expression in HNSCC. Conclusion: hTERT is activated in HNSCC and its expression is independent from clinical data of patients.

Keywords

References

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