Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Correlation of Clinical Factors with HMGI(Y), p53 and Ki-67 Expression in Squamous Cell Carcinomas of the Head and Neck

두경부 편평세포암에서 HMGI(Y), p53, Ki-67의 발현과 임상인자와의 상관 관계

  • Rho Young-Soo (Department of Otorhinolayngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Park Jun-Young (Department of Otorhinolayngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Park Il-Seok (Department of Otorhinolayngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Lim Young-Chang (Department of Otorhinolayngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Moon Sung-Ho (Department of Otorhinolayngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Kim Sung-Dong (Department of Otorhinolayngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Hwang Joon-Sik (Department of Otorhinolayngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Kim Duk-Hwan (Department of Pathology, Hallym University College of Medicine)
  • 노영수 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 박준영 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 박일석 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 임영창 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 문성호 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김성동 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 황준식 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김덕환 (한림대학교 의과대학 해부병리학과교실)
  • Published : 2002.05.01
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Abstract

Objectives: Expression of HMGI(Y), a nucleoprotein that binds to A/T rich sequences in the minor groove of the DNA helix, is observed in neoplastically transformed cells but not in normal cells. We have analyzed HMGI(Y), p53 expression and Ki-67 labelling index in squamous cell carcinomas of the head and neck, and evaluated its clinicopathologic significance. Materials and Methods: 40 cases of squamous cell carcinoma of the head and neck were entered on the study of immunohistochemical stains for HMGI(Y), p53 and Ki-67. We analyzed the relationship between HMGI(Y), p53, Ki-67 expression and age, sex, primary tumor site, stage, survival rate, recurrence. Results: HMGI(Y) expression evidenced by immunohistochemical staining was observed in 35 of 40 (87.5%) squamous cell carcinoma of the head and neck. But no significant correlation was observed between HMGI(Y) expression and other clinical factors such as primary site, tumor stage, differenciation, cervical lymph node, metastasis, recurrence and immunohistochemical status of p53. The Ki-67 labelling index was significantly correlated with recurrence and HMGI(Y) expression (p<0.05). Conclusion: This results suggest the Ki-67 is a good prognostic factor and the HMGI(Y) expression plays some roles in carcinogenesis and cellular proliferation of squamous cell carcinoma of the head and neck. HMGI(Y) gene can be used as a cancer marker, the correlation between the gene expression and the prognosis of the cancer patient should be proved in the future studies.

Keywords

References

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