Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Association Study of the Relationship between Endometriosis and Polymorphism of p53 Codon 72

p53 Codon 72 다형성과 한국인 여성의 자궁내막증의 연관성에 관한 연구

  • Hur, Sung-Eun (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University) ;
  • Shim, Soung-Shin (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University) ;
  • Lee, Kyung-Soon (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University) ;
  • Moon, Hye-Sung (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University) ;
  • Yu, Han-Ki (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University) ;
  • Chung, Hye-Won (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University)
  • 허성은 (이화여자대학교 의과대학 산부인과학교실) ;
  • 심성신 (이화여자대학교 의과대학 산부인과학교실) ;
  • 이경순 (이화여자대학교 의과대학 산부인과학교실) ;
  • 문혜성 (이화여자대학교 의과대학 산부인과학교실) ;
  • 유한기 (이화여자대학교 의과대학 산부인과학교실) ;
  • 정혜원 (이화여자대학교 의과대학 산부인과학교실)
  • Published : 2002.12.30
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Abstract

Objective: The present study was performed to evaluate the association o f p53 codon 72 polymorphism and endometriosis. Materials and Methods: We investigate 74 women who were operated for endometriosis and 93 women who had no endometriotic lesion proved by operation. Polymerase chain reaction was used to detect p53 codon polymorphisms. Result: We have found no significant difference between endometriosis and control group in the p53 codon polymorphism. The respective proportion of arginine homozygotes, heterozygotes and proline homozygotes in endometriosis group were 18.9%, 62.2% and 18.9%, respectively, and were 12.9%, 75.2% and 11.9%, respective in the group without endometriosis. Conclusion: Endometriosis is not associated with p53 polymorphism in Korean endometriosis patients.

Keywords

References

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