Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
권호 표지

Reference Value of Mercury in Liver and Kidney of Korean

한국인의 간과 콩팥조직 내 수은 함유량의 참고치

  • 최병선 (중앙대학교 의과대학 예방의학교실) ;
  • 박영주 (중앙대학교 의과대학 예방의학교실) ;
  • 권일훈 (국립과학수사연구소) ;
  • 홍연표 (중앙대학교 의과대학 예방의학교실) ;
  • 박정덕 (중앙대학교 의과대학 예방의학교실)
  • Published : 2002.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was conducted to investigate the reference value of mercury (Hg) in liver and kidney of Korean population. The mercury concentration in 244‘sudden and unexpected death’autopsies (male: 180, female: 64) aged from 0 to 87 years was analyzed. The concentration of mercury was measured by atomic absorption spectrophotometer (Perkin-Elmer Model 5100) with mercury/hydride generating system (FIAS 400). The contents of mercury in liver and kidney fitted well the log-normal distribution rather than normal distribution. Geometric mean concentration of mercury in liver and kidney was 0.115 $\mu\textrm{g}$/g wet weight and 0.149 $\mu\textrm{g}$/g wet weight, respectively. Geometric mean concentration of mercury in female was higher than in male (p < 0.01). The mercury content in liver and kidney increased with age up to the forties and slightly decreased there-after. The regression model of mercury deposit in liver and kidney by age was predicted as the following equation : Log LHg : -1.0576＋0.0045$.$Age-0.0001$.$Age$^2$＋0.0873$.$Sex, Log KHg = -1.0576＋0.0152$.$Age-0.0002$.$Age$^2$＋0.1935$.$Sex. The liver burden of mercury was estimated to be 158.3∼161.3 $\mu\textrm{g}$ in male and 163.0∼166.9 $\mu\textrm{g}$ in female. The kidney burden of mercury was estimated to be 42.0∼42.9 $\mu\textrm{g}$ in male and 55.5∼57.1 $\mu\textrm{g}$ in female.

Keywords

References

  1. 김용선, 정규철. 우리나라 정상인의 혈중 수은량. 예방의학회지. 1983; 15(1): 75-82
  2. 우상덕, 이민규, 황우전, 윤중진, 민병혁, 윤성구. 국립과학수사연구소연보. 1965;4;129-149
  3. 유영찬, 이상기, 양자열, 김기욱, 이수연, 정규혁. 한국인 모발과 내부장기조직간 Cd, Hg, Pb 및 Zn 함량의 상호 관련성. 환경독성확회지.2002;17(1): 21-27
  4. 이원식, 김두희. 어패류와 그 제품 섭취양상에 따른 두발 중 총수은 및 유기수은 함량. 예방의학회지. 1994;27(1): 44-58
  5. 장미영, 김광종, 염용태. 직업성 수은중독 집단발생에 관한 실험역학적 연구. 고려의대논집.1989;26(1):67
  6. Gabica J. Benson W. Loomis M. Total mercury levels in selected human tissues. Idaho-1973-74(1, 2). Pestic. Monit. J. 1975; 9(2): 59-63
  7. Herrstrom P. Holmen A, Karlsson A, Raihle G, Schutz A. Hogstedt B. Immune factors, dental amalgam and low-dose exposure to mercury in Swedish adolescents. Arch. Environ. Health. 1994; 49(3): 160-164 https://doi.org/10.1080/00039896.1994.9940376
  8. Joselow MM. Goldwater LJ. Weinberg SB. Absorption and excretion of mercury in man. XI. Mercury content of 'normal' human tissues. Arch. Environ. Health. 1967; 15(1) : 64-66 https://doi.org/10.1080/00039896.1967.10664875
  9. Kevorkian J. Cento DP. Hyland JR, Bagozzi WM. Van Hollebeke E. Mercury content of human tissues during the twentieth century. Am. J. Public Health. 1972; 62(4) : 504-513 https://doi.org/10.2105/AJPH.62.4.504
  10. Matsuo N. Suzuki T. Akagi H. Mercury concentration in organs of contemporary Japanese. Arch. Environ. Health. 1989; 44(5): 298-303 https://doi.org/10.1080/00039896.1989.9935897
  11. Mottet NK. Body RL. Mercury burden of human autopsy organs and tissues. Arch. Environ. Health. 1974; 29(1): 18-24 https://doi.org/10.1080/00039896.1974.10666520
  12. Muramatsu Y. Parr RM. Concentrations of some trace elements in hair. liver and kidney for autopsy subjects-relationship between hair and internal organs. Sci. Total Environ. 1988; 76(1): 29-40 https://doi.org/10.1016/0048-9697(88)90280-X
  13. Parker MM, Humoller FL. Mahler DJ. Determination of copper and zinc in biological material. Clin. Chem. 1967; 13(1): 40-48
  14. Putman JJ. Quicksilver and slow death. Natl. Geogr. Mag. 1972; 144:507
  15. Saryan LA. Zenz C. Lead and its compounds. In : Zenz C, editors. Occupational Medicine. 3rd ed. St. Louis: Mosby; 1994; p.547-582
  16. Schiele R, Freitag EM, Schaller KH, Schellmann B, Welte D. Study on the normal mercury concentrations of human organs. Zentralbl. Bakteriol. Mikrobiol. Hyg. 1981; 173(1-2): 45-62
  17. Suzuki T, Hongo T, Yoshinaga J, Imai H, Nakazama M, Matsuo N, Akagi H. The hair-organ relationship in mercury concentration in contemporary Japanese. Arch. Environ. Health. 1993; 48(4): 221-229 https://doi.org/10.1080/00039896.1993.9940363
  18. Weiner JA, Nylander M. The relationship between mercury concentration in human organs and different predictor variables. Sci. Total Environ. 1993; 138(1-3): 101-115 https://doi.org/10.1016/0048-9697(93)90408-X
  19. WHO. Environmental Health Criteria 1: Mercury. Geneva: World Health Organization; 1976; p.131
  20. Yukawa M, Amano K, Suzuki-Yasumoto M, Terai M. Distribution of trace elements in the human body determined by neutron activation analysis. Arch. Environ. Health. 1980; 35(1): 36-44 https://doi.org/10.1080/00039896.1980.10667459