Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Resveratrol Induces the Apoptosis of Osteosarcoma Saos-2 Cells

레스베라트롤에 의한 골육종 Saos-2 세포의 세포고사

  • 이현장 (원광대학교 의과대학 미생물학교실) ;
  • 양재현 (원광대학교 의과대학 미생물학교실) ;
  • 최익준 (원광대학교 의과대학 미생물학교실) ;
  • 최이천 (원광대학교 의과대학 미생물학교실) ;
  • 김용권 (원광대학교 의과대학 미생물학교실) ;
  • 임창인 (원광대학교 의과대학 미생물학교실) ;
  • 윤재도 (원광대학교 의과대학 미생물학교실) ;
  • 김호찬 (원광대학교 의과대학 미생물학교실) ;
  • 원진숙 (전북대학교 의과대학 생화학교실)
  • Published : 2002.09.01
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Abstract

Resveratrol, a phytoalexin found in grapes, berries, and peanuts, is one of the most promising agents for cancer prevention. Recent studies show that the antitumor activity of resveratrol occurs through p53-mediated apoptosis. This study demonstrated the mechanism that resveratrol induced apoptosis in human osteosarcoma Saos-2 cells lacking p53. Treatment of osteosarcoma Saos-2 cells with resveratrol resulted in decrease of cell viability, which was revealed as apoptosis characterized by activation of caspase-3 protease as well as cleavage of poly(ADP-ribose) polymerase (PARP) with change of mitochondrial membrane potential transition. These results suggest that resveratrol may be potentially useful to treat osteosarcoma via activation of caspase protease and mitochondrial dysfunction.

Keywords

References

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