Journal of Korean Academy of Nursing (대한간호학회지)

Korean Society of Nursing Science (한국간호과학회)
권호 표지

Effect of DHEA Administration before, during and after Dexamethasone Treatment on Body Weight and Mass of TypeI,II Muscles in Rats

DHEA의 투여 시기가 Dexamethasone 치료 쥐의 체중과 TypeI,II 근육무게에 미치는 영향

  • Published : 2002.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was to determine the effect of DHEA administration before, during, and after dexamethasone treatment on body weight and TypeI,II muscle weight of rat receiving dexamethasone treatment. Method: Wistar rats were divided into 6 groups: control(C), dexamethasone(D), DHEA administration for 3days after dexamethasone treatment for 7days(7D+3DH), dexamethasone treatment for 7days after DHEA administration for 3days(3DH+7D), DHEA administration during dexamethasone treatment for 4days after dexamethasone treatment for 3days(3D+4DDH), DHEA administration during dexamethasone treatment for 7days(7DDH). Dexamethasone was injected by subcutaneously daily at a dose of 5mg/kg. DHEA was orally administered daily at a dose of 5mg/kg for 7 days. Soleus(TypeI) muscle, and both plantaris and gastro- cnemius(TypeII) muscles were dissected on the 7th day of experiment. Result: Body weight of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Body weight of 7D+3DH group decreased significantly compared with that of 7D group, 7DDH group, 3DH+7D group and 3D+4DDH group. Muscle weight of both plantaris and gastro- cnemius tended to decrease compared with that of 7D group. Muscle weight of 7DDH group, 3D+4DDH group and 3DH+7D group increased significantly compared with that of 7D+3DH group. Muscle weight of gastrocnemius of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Conclusion: Based on these results, it can be suggested that DHEA administration before and during dexamethasone treatment can increase both body weight and mass of atrophied TypeII muscle induced by dexa- methasone treatment.

Keywords

References

  1. Araneo, B. & Daynes, R. (1995). DHEA functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury. Endocrinology, 136, 393-401 https://doi.org/10.1210/en.136.2.393
  2. Blauer, K. L., Poth, M., Rogers, W. M, & Bernton, E. W. (1991). DHEA antagonizes the suppressive effects of dexamethasone on lymphocyte proliferation. Endocrinology, 129, 3174-3179 https://doi.org/10.1210/endo-129-6-3174
  3. Choe, M. A, Choi, J. A. & Shin, G. S. (1997). Effect o regular exercise on body weight, hindlimb muscles and adrenal gland of young rats. J Korean Acad Nurs, 27(3), 510-519
  4. Choe, M. A, Shin, G. S., Lee, E. J. & An, G. J. (2001). Effect of DHEA administration during dexamethasone treatment on mass of hindlimb muscles of rat. J Korean Bio Nurs Sci, 3(1), 63-74
  5. Czerwinski, S. M., Kurowski, T. G., O'Neill, T. M., & Hickson, R. C. (1987). Initiating regular exercise protects against muscle atrophy from glucocorticoids. J APPl Physiol, 63(4), 1504-1510
  6. Decramer, M., Laquet, L. M, Fagard, R & Rogiers, P. (1994). Corticosteroids contribute to muscle weakness in chronic air-flow obstruction. Am J Respir Crit Care Med, 150, 11-16
  7. Falduto, M. T., Young, A. P. & Hickson, R C. (1992). Exercise inhibits glucocorticoid-induced lutamine synthetase expression in red skeletal muscles. Am J Physiol, 262(Cell Physiol. 31), C214-C220
  8. Fryburg, D. A. , Jahn, L. A, Hill, S. A, Oliveras, D. M., and Barrett, E. J. (1995). Insulin and insulin-ike growth factor- I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanism J Clin Invest, 96, 172-1729
  9. Gardiner, P. F., Hilb, B., Simpson, D. R, Roy, R. R. & Edgerton, V. R. (1980). Effect of mild weight lifting program on the progress of glucocorticoid induced atrophy in rat hindlimb muscle. Pfluegers Arch, 385, 147-153 https://doi.org/10.1007/BF00588695
  10. Goldfarb, A. H, McIntosh, M. K, Boyer, B. T. & Fatouros, J. (1994). Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rat. J APPl Physiol, 76(4), 1630-1635
  11. Griggs, R. C., Kingston, W., Josefowicz, R. F., Herr, B. F., Forbes, G., and Haliday, D. (1989). Effects of testosterone on muscle mass and muscle protein synthesis. J Appl Physiol, 66, 498-503
  12. Hickson, R. C., Kurowski, T. T., Andrews, G. H, Capaccio, J. A., & Chatterton, R. T. (1984). Androgen cytosol binding in exercise-induced sparing of muscle atrophy. American Journal of Physiology., 247, E597-E603
  13. Hornsby, P. (1997). DHEA: A biologist's perspective. J Am Geri Soc, 45(11), 1395-1401
  14. Khan, M. A.(1993). Corticosteroid therapy in Duchenne muscular dystrophy. J Neurol Sci, 120, 8-14 https://doi.org/10.1016/0022-510X(93)90017-S
  15. Nava, S., Gayan-Ramirez, G., Rollier, H, Bisshop, A, Dom, R, Bock, V. & Decramer, M. (1996). Effects of acute steroid administration on ventilatory and peripheral muscles in rats. Am J Respir Crit Care Medicine, 153, 1888-1896
  16. Shapiro, R. & Simmons, R. L. (1992). Renal transplantation. New York: Gower
  17. Swenson, C. D., Cottesman, S. R, Belsito, D. V., Samanich, K. M, Edington, J. & Thorbecke, G. J. (1995). Relationship between humoral immunoagementing properties of DHEAS and Ig D-receptor expression in young & aged mice. Ann NY Acd. Sci. 774, 294-258
  18. Tagliaferro, A. R., Davis, J. R., Truchon, S. & Hamont, N. (1986). Effect of DHEA on metabolism, body weight and comparison of male and female rat. J Nutr, 116, 1977-1983