한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제12권2호
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- Pages.65-70
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- 2002
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
급성 비천공성 충수염 수술시 예방적 항균제의 사용기간
Appropriate Duration of Prophylactic Antibiotics in Acute Nonperforated Appendicitis
- Suh, Ok Kyung (College of Pharmacy, Seoul National University) ;
- Kang, Sung Hee (Department of Pharmacy, Kangnam General Hospital) ;
- Yang, Dae Hyun (General Surgery, Kangnam General Hospital) ;
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Shin, Wan Gyoon
(College of Pharmacy, Seoul National University)
- 발행 : 2002.12.01
초록
Prophylactic antibiotics in acute nonperforated appendicitis have been used for preventing infection after appendectomy. However, duration of antibiotic administration for surgical prophylaxis in Korea has been noted to be longer than those recommended in other countries. The objective of this study was to identify appropriate duration of prophylactic antibiotics in acute nonperforated appendicitis by comparing two different antibiotic regimens for their wound infection rates. Eighty-four acute nonperforated appendicitis patients were enrolled in this prospective, randomized, open trial and were assigned to one of two antibiotic regimens: cefoxitin 1 g every 8 hours given intravenously for 24hours or cefoxitin 1 g every 8 hours given intravenously plus sisomicin 75 mg every 12 hours given jntramuscularly for 72 hours. First doses were given just prior to the induction of anesthesia. Postoperative wound infections were detected in