The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effects of HangAmDan(HAD) on Anti-Metastasis and Preventing Relapses, Administered to 69 Cancer Patients

각종 암환자 69례에 대한 항암단의 항전이 및 재발억제효과

  • Lee, Yong-Yeon (East-West Cancer Center, Oriental Hospital of Daejeon University) ;
  • Song, Kee-Cheol (East-West Cancer Center, Oriental Hospital of Daejeon University) ;
  • Choi, Byung-Lyul (East-West Cancer Center, Oriental Hospital of Daejeon University) ;
  • Seo, Sang-Hoon (East-West Cancer Center, Oriental Hospital of Daejeon University) ;
  • Cho, Jung-Hyo (East-West Cancer Center, Oriental Hospital of Daejeon University) ;
  • Lee, Yeon-Weol (East-West Cancer Center, Oriental Hospital of Daejeon University) ;
  • Son, Chang-Gue (East-West Cancer Center, Oriental Hospital of Daejeon University) ;
  • Cho, Chong-Kwan (East-West Cancer Center, Oriental Hospital of Daejeon University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Oriental Hospital of Daejeon University)
  • 이용연 (대전대학교 부속 한방병원 동서암센터) ;
  • 송기철 (대전대학교 부속 한방병원 동서암센터) ;
  • 최병렬 (대전대학교 부속 한방병원 동서암센터) ;
  • 서상훈 (대전대학교 부속 한방병원 동서암센터) ;
  • 조정효 (대전대학교 부속 한방병원 동서암센터) ;
  • 이연월 (대전대학교 부속 한방병원 동서암센터) ;
  • 손창규 (대전대학교 부속 한방병원 동서암센터) ;
  • 조종관 (대전대학교 부속 한방병원 동서암센터) ;
  • 유화승 (대전대학교 부속 한방병원 동서암센터)
  • Published : 2002.06.30
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Abstract

Purpose : Among numerous biological symptoms of cancer, matrix metalloproteinases (MMPs) are essential for tumor invasion and metastasis. HAD is used as an inhibitor of MMP gene. This study was designed to evaluate the effects of HAD on anti metastasis and preventing recurrence in cancer patients. Materials and Methods : We retrospectively analyzed the medical records of 69 cancer patients who had been administered with HAD for over 12 months continuously in East-West Cancer Center of Oriental Hospital of Daejeon University, from January 1993 to May 2002. Results : We analyzed gender, portion, stage and anti-metastasis & recurrence rates of cancer patients. Analysis of sex cases showed that the percentage of male is 62.3%, female is 37.7%. Analysis of cancer portion showed that the percentage of stomach is 31.9%, colorectum is 26.1%, lung is 21.7%, liver is 8.7%, breast is 8.7% Analysis of stage showed that the rate of III is 78.3%, IV is 13.0% and II is 8.7%. Analysis of anti-metastasis and recurrence rates showed that colorectal cancer is 77.8%, stomach cancer is 63.6%, lung cancer is 33.4% and breast cancer is 33.3% (mean : 53.6%). Conclusions : HAD has significant effects on anti-metastasis and preventing recurrence of tumor on cancer patients. So it helps to prolong the survival rates of cancer patients.

Keywords

References

  1. Annual report on the cause of death statistics National statistical office
  2. 종양학 서울대학교의과대학(편)
  3. Breast Cancer Res. Treat v.9 Review biologic heterogeneity of cancer metastasis Fidler, I.J.
  4. Nature Medicine v.1 Angiogenesis in cancer, vascular, rheumatoid, and other disease Folkman, J.
  5. Pharmac. Ther. v.63 Angiogenesis inhibition : a review Auerbach, W.;Auerbach, R.
  6. Cancer J. Sci. Am. v.4 New developments in angiogenesis : a major mechanism for tumor growth and target for therapy Jones, A.;Harris, A.L.
  7. Lancet. v.349 Antiangiogenesis for cancer therapy Harris, A.L.
  8. Cancer J. v.6 Angiogenesis and cancer metastasis Fidler, I.J.
  9. 碩士學位論文 桂枝가 Angiogenesis의 抑制機轉에 미치는 影響 姜玧熙
  10. 碩士學位論文 鬱金이 Angiogenesis의 抑制機轉에 미치는 影響 成熙根
  11. 碩士學位論文 沒藥散이 血管新生抑制에 미치는 效果에 대한 硏究 姜大寅
  12. 碩士學位論文 活絡效靈丹이 Angiogenesis 抑制機轉에 미치는 影響 羅琪煥
  13. 碩士學位論文 加味慈挑丸의 Angiogenesis 抑制效果에 관한 實驗的 硏究 姜顯淑
  14. Study on the anti-metastasis and immune activity of HangAmDan Kim, S.D.
  15. Korean J. of oriental medicine v.2 no.1 Antitumor effects of HangAmDan(HAD) on 55 patients with advanced gastric cancer Yoo, H.S.;Son, C.K.;Cho, C.K.
  16. 대한항방종양학회지 v.6 no.1 항암단을 투여한 대장암환자 83례에 대한 임상보고 이용연
  17. Prescripsion Book Oriental Hospital of Daejeon University
  18. 韓方臨床腫瘍學 趙鍾寬
  19. Eur. J. Cancer v.32A Experimental&clinical studies on the use of MMPIs for the treatment of cancer Talbot, D.C.
  20. 山東中醫雜誌 v.14 癌症復發與轉移的病機及中醫治療探討 劉宇龍(等)
  21. 黃帝內經 洪元植(編)
  22. Angiogenesis Inhibitors in Clinical Trials NCI
  23. J. Cell v.160 Inhibition of angiogenesis by tissue inhibitor of metalloproteinase Johnson, M.D.;Kim, H.R.;Chesler, L.(et al.)
  24. Invest. Ophthalm. Visual Sci. v.38 Inhibition of angiogenesis and tumor growth by matrix-bound tissue inhibitor of metalloproteinase-3(TIMP-3) Anand-Apte, B.;Pepper, M.S.;Bao, L.(et al.)
  25. Science v.248 Identification of aninhibitor of seovascularization from cartilage Moses, M.A.;Sudhalter, J.;Langer, R.
  26. Cancer Res. v.56 Overexpression of tissue inhibitor of metalloproteinase-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion Imren, S.;Kohn, D.B.;Shimada, H.(et al.)
  27. J. Natl. Cancer Inst. v.86 Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1 Khokha, R.
  28. Cancer Res. v.52 Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases DeClerck, Y.A.;Perez, N.;Shimada, H.(et al.)
  29. Cancer Res. v.54 Effects of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spotaneous metastasis of a human melanoma cell line Montgomery, A.M.;Mueller, B.M.;Reisfeld, R.A.(et al.)
  30. Oncogen v.13 Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice Martin, D.C.;Ruther, U.;Sanchez-Sweatman, O.H.(et al.)
  31. J. Cell Physiol. v.157 Tissue inhibitor of metalloproteinase-2 inhibits bFGF induced human microvascular endothelial cell proliferation Murphy, A.N.;Unsworth, E.J.;Stetler-Stevenson, W.G.
  32. Eur. J. Cancer v.30A Protease inhibitors:role and potential therapeutic use in human cancer DeClerck, Y.A.;Imren, S.
  33. Clin. Cancer Res. v.4 Phase I study of intraperitoneal metalloproteinase inhibitor BB94 in patients with malignant ascites Beattie, G.J.
  34. J. Korean cancer assoc. v.27 Expression of matrixmetalloproteinases in gastric cancer as new targets for biotherapy Chung, H.C.
  35. Modern Patho. v.7 Prognosis of gastric carcinoma revealed by interactions between tumor cell & basement membrane Grigioni, W.F.
  36. 歷代中醫腫瘤案論選 余桂淸
  37. Clinical study in 320 cases for cancer patients in the effect Hangamdan Cho, J.H.
  38. 대한동의생리병리학회지 v.15 no.3 청간산과 항암단을 통한 간암 환자 67례에 대한 임상연구 서상훈
  39. J. Korean Cancer Assoc. v.32 no.6 Recurrence of gastric adenocarcinoma and its relating Factors Lee, S.I.
  40. 항암화학요법의 최신동향 대장암의 화학요법 이상재
  41. 암 동서의 결합치료 문구
  42. 대한암학회지 v.30 no.2 말기암환자의 생존기간 및 예후인자에 관한 후향적 코호트 연구 윤영호
  43. J. Korean Med. Assoc. v.35 no.4 Systemic treatment of breast cancer Bang, Y.J.;Kim, N.K.
  44. Cancer, Principles and Practice of Oncololgy Cancer of the breast Harris, J.;Morrow, M.;Norton, L.;Devita, V.T. Jr.(ed.);Hellma, S.(ed.);Rosenberg, S.A.(ed.)
  45. Br. J. Cancer v.74 A multicentre phase II study of docetaxel 75 mg m-2 as first-line chemotherapy for the Clinecal Screening Group of the EORTC Dieras, V.;Chevallier, B.;Kerbrat, P.;Krakowski, I.;Roche, H.;Misset, J.L.;Lentz, M.A.;Azli, N.;Murawsky, M.;Riva, R.;Pouilart, P.;Fumoleau, P.