Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of 6,7-Dichloro-5,8-phthalazinedione and Its Derivatives

  • Published : 2002.10.20
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Abstract

An efficient procedure for the synthesis of 6,7-dichloro-5,8-phthalazinedione (4) was developed in 49% overall yield via chloroxidation of 5,8-diaminophthalazine (8). And a series of its derivatives, 7-pyridinium-5,8-phthalazinedione-6-oxide (9), 6-chloro-7-phenylamino-5,8-phthalazinedione (10), 6,6-dimethoxy-6H-2,3,6b,11-tetraazabenzo[a]fluoren-5-one (11a), and 6,6-diethoxy-6H-2,3,6b,11-tetraazabenzo[a]fluoren-5-one (11b) have been synthesized.

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References

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  1. Synthesis of 6,7-Dichloro-5,8-phthalazinedione and Its Derivatives. vol.34, pp.12, 2002, https://doi.org/10.1002/chin.200312147
  2. Synthesis and antifungal activity of 6-arylamino-phthalazine-5,8-diones and 6,7-bis(arylthio)-phthalazine-5,8-diones vol.17, pp.9, 2002, https://doi.org/10.1016/j.bmcl.2007.02.003
  3. Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition vol.16, pp.8, 2002, https://doi.org/10.1016/j.bmc.2008.02.049