토끼에서 후방십자인대 손상 후 후방십자인대의 기계적 수용기의 변화

The change of the Mechanoreceptor of Posterior Cruciate Ligament after Posterior Cruciate Ligament Injury in the Rabbit

목적 : 토끼후방십자인대의절단뒤후방십자인대의치유와기계적수용기의수적변화에대해관찰하고자하였다. 대상및방법 : 골성숙이완료된열마리의뉴질랜드산흰토끼를 이용하여각각에서양측슬관절중한쪽슬관절에서는후방십자인대를절단하고, 다른한쪽에는샴술기를시행한후20주후에생검하여후방십자인대의치유가이루어진9례에서조직학적검사를시행하여후방십자인대를절단한슬관절과샴술기를시행한슬관절을비교하였다. 결과 : 후방십자인대절단후치유가이루어진조직들에서샴술기를시행하였던조직보다기계적수용기가약간감소한것으로관찰되었으나통계적유의성은없었다. 결론 : 후방십자인대가손상된슬관절에서비록기계적수용기가감소한다할지라도고유감각이유지될수있을것으로사료되나기계수용기의손상된후방십자인대에대한작용과생역학적기능에대해서는좀더연구가이루어져야될것으로사료된다.

Purpose : To assess the change in the number of mechanoreceptors of posterior cruciate ligament(PCL) after transecting posterior cruciate ligament of the rabbit. Materials and Methods : We selected 10 skeletally-matured New Zealand white rabbits and one of the two posterior cruciate ligaments was transected and the other underwent sham-operation on each rabbit. Afterward, PCLs with synovium were obtained at femoral attach area in both knees in 20 weeks postoperatively, but in one of the cases, the transected PCL did not heal and had to be excluded from this study. Consequently, histologic examination of the ligament for the remaining 9 cases was done after being prepared with modified gold chloride stain. Results : The study showed a little bit more decrease in the number of mechanoreceptors in the transected group compared with that in the sham-operated group, but the number was statistically negligible. Conclusions : It is considered that the knee joint with injured PCL may still maintain proprioception since the decrease in the number of mechanoreceptors is not considerable, but further study on biomechanical role and function of mechanoreceptor of healed PCL is required.