진폐증 환자에서의 혈청학적 표지자의 변화

The Changes of Serologic Markers in Pneumoconiosis of Coal Workers

  • 유광하 (건국대학교 의과대학 내과학교실) ;
  • 윤호상 (건국대학교 의과대학 내과학교실) ;
  • 이상엽 (건국대학교 의과대학 내과학교실) ;
  • 진춘조 (건국대학교 의과대학 내과학교실) ;
  • 안철민 (연세대학교 의과대학 내과학교실) ;
  • 김형중 (연세대학교 의과대학 내과학교실)
  • Yoo, Kwang-Ha (Department of Internal Medicine, Konkuk University College of Medicine) ;
  • Yun, Ho-Sang (Department of Internal Medicine, Konkuk University College of Medicine) ;
  • Lee, Sang-Yeup (Department of Internal Medicine, Konkuk University College of Medicine) ;
  • Jin, Choon-Jo (Department of Internal Medicine, Konkuk University College of Medicine) ;
  • Ahn, Cheol-Min (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Hyung-Joong (Department of Internal Medicine, Yonsei University College of Medicine)
  • 발행 : 2001.05.31

초록

Background : Pneumoconiosis is a parenchymal lung disease that results from the accumulation of coal dust in the lungs and the consequent tissue reaction. To evaluate the role of various personal factors in pneumoconiosis and the significance of some serologic markers for assessing the disease activity related to pneumoconiosis, the Rheumatoid Factor(RF), ${\alpha}_1$-AT, C-Reactive Protein(CRP), ceruloplasmin and fibrinogen levels were measured. Method : All the patients were males, 45-76 years old, and the mean duration of coal dust exposure was 23.2 years. 51 patients were classified as having Simple Pneumoconiosis (SP), 59 had Progressive Massive Fibrosis (PMF). Fifty eight men with ages ranging from 26-70 years were used as normal controls. The serum RF and CRP were titrated using an Autochemistry analyzer (HITACHI 7150 : Japan) and the ${\alpha}_1$-AT and ceruloplasmin levels were measured using a Nephelometer (Behring Nephelometer : Germany) and the fibrinogen levels were estimated by using an Autoanalyzer for hematologic coagulation. Result : There was a higher RF level in the SP, and PMF groups than in the control groups but there was no statistical difference. The CRP, ${\alpha}_1$-AT, and ceruloplasmin levels were also higher in the SP, and PMF groups. However, the fibrinogen concentration was within the normal ranges in both the SP and PMF groups. Conclusion : The CWP (Ed note : Define CWP) patients had significantly higher CRP, ${\alpha}_1$-AT, and ceruloplasmin levels compared to the control group. It is believed that these serologic changes could be used as a marker of the disease activity.

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