Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Histologic Study on Tissue Response of Various Resorbable Membranes in Rats

수종의 흡수성 차폐막의 조직반응에 관한 비교연구

  • Ryu, Ho-Chul (Department of Periodontology, Division of Dentistry, Graduate school, Kyung Hee University) ;
  • Kwon, Young-Hyuk (Department of Periodontology, Division of Dentistry, Graduate school, Kyung Hee University) ;
  • Park, Joon-Bong (Department of Periodontology, Division of Dentistry, Graduate school, Kyung Hee University) ;
  • Herr, Yeek (Department of Periodontology, Division of Dentistry, Graduate school, Kyung Hee University)
  • 류호철 (경희대학교 치과대학 치주과학교실) ;
  • 권영혁 (경희대학교 치과대학 치주과학교실) ;
  • 박준봉 (경희대학교 치과대학 치주과학교실) ;
  • 허익 (경희대학교 치과대학 치주과학교실)
  • Published : 2001.03.30
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Abstract

The purpose of this study is to evaluate histologically the resorption and tissue response of various resorbale membranes used for guided tissue regneration procedures, using a subcutaneous model on the dorsal surface of the rat. In this study, 12 Sprague-Dawley male rats(mean BW 150gm) were used and the commercially available materials included dense collagen membrane, freeze-dried bovine dura mater loos collagen membrane, PLA/PLGA membrane. Animals were sacrificed at 3, 6 and 8 weeks after implantation of various resorbable membranes. Specimens were prepared with Hematoxylin-Eosin stain for light microscopic evaluation. The results of this study were as follows: 1. Resorption : Loose collagen membrane group was resorbed most rapidly. Dense collagen membrane group and freeze-dried bovine dura mater group were rarely resorbed. 2. Inflammatory reactions : PLA/PLGA membrane group showed persistent and severe inflammatory reactions for 3 to 8 weeks. Moderate inflammatory reactions and the ectopic formation of calcified material were observed in dense collagen membrane group. Freeze-dried bovine dura mater group and loose collagen membrane group showed mild inflammatory reactions 3. In PLA/PLGA membrane group, multinucleated giant cells by foreign body reactions were observed. In conclusion, the resorption of freeze-dried bovine dura mater didn't happen for 3-6weeks, which showed the best bio-compatibility. Therefore, freeze-dried bovine dura mater was considered proper resorbable membrane for guided tissue regeneration.

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