The korean journal of orthodontics (대한치과교정학회지)
- Volume 31 Issue 2 Serial No. 85
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- Pages.237-248
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- 2001
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- 2234-7518(pISSN)
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- 2005-372X(eISSN)
Effects of Estrogen and Progesterone on the Proliferation and Activity of Osteoblastic cells Abstract
에스트로젠과 프로게스테론이 골모세포의 증식과 활성에 미치는 영향
- Ha, Kook-Bong (Department of Orthodontics, College of Dentistry, Pusan University) ;
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Kim, Se-Won
(Department of Dental Pharmachology, College of Dentistry, Dan Kook University) ;
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Son, Woo-Sung
(Department of Orthodontics, College of Dentistry, Pusan University)
- Published : 2001.04.30
Abstract
Biomechanical reactions of tooth movement are the combination of bone formation and resorption, in which many paracrine factors are involved. The sex hormone is one of the paracrine factors and the sex hormonal level of an adult female vanes according to the body condition, e.g. mensturation, pregnancy, postmenopause, etc. Although the exact mechanism is not clarified yet, estrogen and progesterone are known to regulate the function of osteoblast. Again osteoblast is reported to affect the function of osteoclast. The purpose of this study is to determine the influence of the female sex hormone, estrogen and progesterone, on the cell proliferation and activity of HOS and ROS17/2.8 cell line. The observed results were as follows. 1. Estrogen inhibited HOS cell proliferation and promoted ROS17/2.8 cell proliferation. 2. Estrogen increased the activity of alkaline phosphatase of HOS cell and reduced the activity of alkaline phosphatase of ROS17/2.8 cell. 3. Progesterone inhibited the proliferation of HOS and ROS17/2.8 cell, but had no influence on the activity of alkaline phosphatase. 4. Estrogen and progeterone did not have any particular effects on the activity of super oxide, nitric oxide and gelatinase of HOS and ROS17/2.8 cell.
치아이동에 대한 생력학적 반응은 골 형성과 재형성의 조합이라 할 수 있다. 골 형성과 흡수에는 국소적으로 작용하는 여러 부분비 인자가 관여한다. 대표적인 여성호르몬인 에스트로젠과 프로게스테론도 그 중의 한 인자로 성인 여성은 생리, 임신, 폐경 등 상태에 따라 체내 성호르몬 농도가 달라진다. 따라서 이러한 농도의 변화에 따라 골조직이 영향을 받을 수 있을 것으로 추정된다. 골모세포는 골흡수를 일으키는 호르몬인 PTH, Vit
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