Detection of Epstein-Barr virus in the inflammatory and neoplastic uterine cervical lesions

자궁경부의 염증 및 종양병변에서 Epstein-Barr 바이러스의 검출

  • Jeong, Hye-Jin (Department of Pathology, College of Medicine, Korea University) ;
  • Lee, Eung-Seok (Department of Pathology, College of Medicine, Korea University) ;
  • Lin, Zhen-Hua (Department of Pathology, College of Medicine, Korea University) ;
  • Park, Seol-Hee (Department of Pathology, College of Medicine, Korea University) ;
  • Kang, Jae-Sung (Department of Obstetrics and Gynecology, College of Medicine, Korea University) ;
  • Kim, In-Sun (Department of Pathology, College of Medicine, Korea University)
  • 정혜진 (고려대학교 의과대학 병리학교실) ;
  • 이응석 (고려대학교 의과대학 병리학교실) ;
  • 림정화 (고려대학교 의과대학 병리학교실) ;
  • 박설희 (고려대학교 의과대학 병리학교실) ;
  • 강재성 (고려대학교 의과대학 산부인과학교실) ;
  • 김인선 (고려대학교 의과대학 병리학교실)
  • Published : 2001.12.30

Abstract

The prevalence of Epstein-Barr virus(EBV) in the uterine cervix was investigated to define the possible etiologic role in cervical carcinogenesis. The viral genotyping and LMP-1 30bp deletion were also stooled. The materials included 169 uterine cervical swabs(152 within normal limits, 12 atypical squamous cells of uncertain significance, 3 low grade intraepithelial lesions, and 2 high grade squamous intraepithelial lesion) and 104 uterine cervical tissues obtained from hysterectomy specimens(32 carcinoma in situ, 9 microinvasive squamous cell carcinomas, 37 invasive squamous cell carcinomas, 7 adenocarcinomas, 7 adenosquamous carcinomas, and 12 cervicitis). EBV detected by PCR for EBNA-1 was positive in 52(56.5%) of 92 invasive and noninvasive cervical carcinomas, and 80(48.8%) of 164 inflammatory or normal cervices. The viruses detected in carcinomas were all type A, and LMP-1 30bp deletion form was more frequent in premalignant and malignant cervical lesions than in nonneoplastic cervices. From the above results, it may be concluded that EBV is one of common viruses detected in uterine cervix of Korean women, and type A virus and LMP-1 30bp deletion form may have a role in cervical carcinogenesis.

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