The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

The Effects of Fractions of Houttuynia cordata THUNB on the Accumulation of Cadmium and Induction of Metallothionein in Rats(IV)

어성초 분획이 흰쥐 장기내 카드뮴 축적과 Metallothionein 생성에 미치는 영향(VI)

  • 이기남 (원광대학교 한의학전문대학원 산업한의학교실) ;
  • 정재열 (원광대학교 한의학전문대학원 산업한의학교실) ;
  • 송용선 (원광대학교 한의학전문대학원 산업한의학교실) ;
  • 이정호 (원광대학교 한의학전문대학원 천연물학교실) ;
  • 유일수 (익산대학 공업화학과) ;
  • 김신기 (익산대학 환경원예과) ;
  • 백승화 (원광대학교 한의학전문대학원 천연물학교실)
  • Published : 2001.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was conducted to investigate the antitoxic effects of Houttuynia cordata THUNB with chloroform and ethyl acetate fractions. The results were as follows: 1. Detoxication effects of chloroform and ethyl acetate fractions of Houttuynia cordata THUNB were increased in proportion to the dosages. Detoxication effects of ethyl acetate fraction of Houttuynia cordata THUNB were higher than chloroform fraction of Houttuynia cordata THUNB's results and detoxication effects in the kidneys were higher than results for the liver. 2. Metallothionein concentrations in the liver were higher than concentrations in the kidneys, and ethyl acetate fraction of Houttuynia cordata THUNB was higher than chloroform fraction of Houttuynia cordata THUNB in induction of metallothionein. 3. After the administration of chloroform and ethyl acetate fractions of Houttuynia cordata THUNB, body weights increased in proportion to chloroform and ethyl acetate fraction s dosage of Houttuynia cordata THUNB but changes of body weight dminished after 3 weeks. From the above results, this study suggests that chloroform and ethyl acetate fraction of Houttuynia cordata THUNB increased metallothionein induction to cadmium intoxication in rat s kidney and liver and decreased the toxicity of cadmium in rats.

Keywords

References

  1. 식품중의 미량금속에 관한 조사연구 v.29 국립보건원
  2. 한국독성학회지 v.12 한국산 생약으로부터 해독물질의 개발(제8보) 금은화 메탄올 분획이 흰쥐 장기내 카드뮴 축적과 metallothionein 생성에 미치는 영향 김영옥;이종섭;박경옥;한두석;유일수;곽정숙;백승화
  3. 약품식물학각론 김일혁
  4. 약초의 성분과 이용 문관심
  5. 한국독성학회지 v.11 한국산 생약으로부터 해독물질의 개발(제4보) 흰쥐 간장내의 카드뮴 축적에 미치는 인삼 추출물의 영향 백승화;유일수;이종섭;한두석
  6. 국민영양(10) 수질오염, 대기오염, 토양오염에 의한 식품오염 이용욱
  7. 대한예방한의학회지 v.3 no.2 어성초 전탕액이 흰쥐 장기내 카드뮴 축적에 미치는 영향(I) 이정호;강길웅;정재열;한종민;이기남';정우영;한두석;유일수;김종수;백승화
  8. 한국노화학회 v.9 천화분 메탄올 추출물의 흰쥐장기내 카드뮴 축적에 미치는 영향(I) 이종섭;김남송;유일수;김종수;이기남;한두석;강길웅;이정호;백승화
  9. 한국영양학회지 v.26 no.2 카드뮴으로 중독된 흰쥐의 간장 및 신장에서의 Metallothionein 합성에 관한 연구 전수영;이순재
  10. Rev. Nutr. Diet. v.32 Cadmium toxicity-nutritional influence and the role of metallothionein world Bremer, I.
  11. Toxicology. v.28 Cellular adaptation in metal toxicology and metallothionein Cherian, M.G.;Nordberg, M.
  12. Korean J. Environ Biol. v.11 no.1 Localization of metallothionein induced by cadmium in rat hepatocyte Choe, R.S.;Kim, O.Y.
  13. Cadmium and Health Cadmium:Uses, Occurrence and Intake Elinder, C.G.;Friberg, L.(et al.)(Eds.)
  14. Biochem. Biophys. Res. Commun. v.40 Mechanism for cadmium and zinc antagonism of copper metabolism Evans, G.W.;Majours, P.F.;Cornatzer, W.E.
  15. Biological roles of metallothionein Foulkes, E.C.(ed.)
  16. Handbook on the Toxicology of Metals Cadmium. Friberg, L.;Kjellstrom,T.;Nordberg, G.
  17. Cadmium in the Environment Friberg, L.
  18. Toxicol. Appl. Pharmacol. v.101 Nonmetallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat Goyer, R.A.;Miller, C.R.;Zhu, S.Y.
  19. Toxicol. Appl. Pharmocol. v.16 Binding of mercury in the rats:Studies using 203HgCl2 and gel filteration Jakubouki, M.;Piotrowski, J.K.;Trojanowska, B.
  20. Int. Arch. Occup. Environ. Health. v.60 Cumulative blood-cadmium and tubular proteinuria:A doseresponse relationship Jaruup, L.;Elinder, C.G.;Spang, G.
  21. Korean J.Nutrition. v.26 no.2 Accumulation for metallothionein in rat liver and kidney by cadium administration Jun, S.Y.;Rhee, S.J.
  22. Cadmium Trace elements in human and animal nutrition(Vol 2) Kostial, K.;Mertz, W.(ed.)
  23. J. Toxicol. Environ. Health. v.5 Normal levels of cadmium in diet, urine, blood and tissures of inhabitants of the United States Kowel, N.E.;Johnson, D.E.;Kaemer, D.F.;Pahren, H.R.
  24. Environ. Res. v.48 A dose-response analysis of cadmuim in the general environment with special reference to total cadmium intake limit Nogawa, K.;Honda, R.;Kido, T.
  25. Toxic Metals. Nordberg, G.F.
  26. Acta. Pharmacol. Toxicol. v.29 Distribution of cadmium among proteins fractions of mouse liver Norberg, G.F.;Piscator, N.;Lind, B.
  27. Cadmium and Health Kinetics and Metabolism Norberg, G.F.;Kjellstrom, T.;Norberg, M.;Friberg, L.(et al.)(Eds.)
  28. Biological Monitoring of Cadmium Biological Monitoring of Toxic Metals. Norberg, G.F.;Nordberg, M.
  29. Am. J. Physiol. v.237 Biological function of metallothionein VII. Effect of age on its metabolism in rats Oh, S.H.;Whanger, P.D.
  30. Eisei Kagaku v.24 A simplified procedure for deterination of metallothionein in animal tissues Onosaka, S.;Tanak, K.;Doi, M.;Okahara, K.
  31. Nord.Hyg.T v.45 On cadmium in normal human kidney together with a report on the isolation of metallothionein from livers of cadmium exposed rabbits Piscator, M.
  32. Toxicol. Lett. v.15 The critical level of cadmium human renal cortex:A reevaluation Roles, H.A.;Lauwerys, R.;Dardenne, A.N.
  33. Br. J. Ind. Med. v.48 Assessment of the filtration reserve capacity of the kidney in workers exposed to cadmium Roles, H.A.;Lauwerys, R.;Bernard, A.M.;Buchet, J.P.;Vos, A.;Oversteyns, M.
  34. American Science v.207 Lead in albocore:Guide to lead pollution Settle, D.M.;Patterson, C.C.
  35. Jap. J. Industrial. Health. v.16 Accumulation and clearance of cadmium, copper and zinc in organs of rat following single injections of cadmium Short communication
  36. Environ. Physiol. Biochem. v.4 Control of cadmium binding protein synthesis in rat liver Squibb, K.S.;Cousin, R.J.
  37. Analytical Aspects and Health Significance v.I Cadmium:Atomic Absorption Spectrometry in Occupational and Environmental Health Practice Tsalev, D.L.;Zaprianov, Z.K.
  38. FEBS.Lett. v.10 Cd, Mn and Zn induced synthesis of nuclear RNA in the livers of normal and adrenal ectomized rats Weser, O.;Hubner, L.