Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Comparison of Skin Response Between New Zealand White Rabbit and Hartley Guinea Pig to Glycolic Acid

Glycolic Acid에 대한 토끼와 기니픽간의 피부자극성 비교

  • 안광수 (식품의약품안전청 국립독성연구소) ;
  • 정경미 (식품의약품안전청 국립독성연구소) ;
  • 김용규 (식품의약품안전청 국립독성연구소) ;
  • 이종권 (식품의약품안전청 국립독성연구소) ;
  • 박기숙 (식품의약품안전청 국립독성연구소) ;
  • 김은정 (식품의약품안전청 국립독성연구소) ;
  • 이선희 (식품의약품안전청 국립독성연구소) ;
  • 홍진태 (식품의약품안전청 국립독성연구소)
  • Published : 2001.03.01
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Abstract

In this study, we compared skin response between Hartley guinea pig and New Zealand white rabbit. New Zealand white rabbit was treated by a glycolic acid (0, 8, 24, 40, 56 mg/$cm^2$) and UVB (0, 0.4, 3.0 J/$cm^2$) for 14 days. Skin irritation by glycolic acid and UVB were increased in dose and time-dependent manners, and the combination treatment of UVB increased glycolic acid-induced skin irritation. Comparison the skin irritation index between guinea pig and rabbit showed that guinea pig was much more sensitive to glycolic acid and UVB. This study indicated that selection of reliable species of animal could be considered in chemical-induced skin irritation study.

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