Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Crtotoxic Triterpenoides from Alismatis Rhizome

  • Lee, Sang-Myung (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kho, Yung-Hee (Korea Research Institute of Bioscience and Biotechnology) ;
  • Min, Byung-Sun (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Jin-Hee (Korea Research Institute of Bioscience and Biotechnology) ;
  • Na, Min-Kyun (College of Pharmacy, Chungnam National University) ;
  • Kang, Shin-Jyung (Department of Life Science, Joongbu University) ;
  • Maeng, Hack-Young (Department of Life Science, Joongbu University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
  • Published : 2001.12.01
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Abstract

Four prostate-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with $ED_50$ values of 7.5, 7.5, $4.9\mu\textrm{g}/ml$, respectively.

Keywords

References

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