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The Pharmaceutical Society of Korea (대한약학회)
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A Cytotoxic Secocycloartenoid from Abies koreana

  • Kim, Hyun-Jung (College of pharmacy, Chonnam National University) ;
  • Le, Quoc-Khanh (College of pharmacy, Chonnam National University) ;
  • Lee, Mi-Hyun (College of pharmacy, Chonnam National University) ;
  • Kim, Tae-Sung (College of pharmacy, Chonnam National University) ;
  • Lee, Hyeong-Kyu (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Lee, Ik-Soo (College of pharmacy, Chonnam National University)
  • Published : 2001.12.01
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Abstract

Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-$9{\beta}$-lanosta-7,22Z,24-trien-26,23-olive (6) were isolated from Abies koreana, together with $\beta$-sitosterol (2), maltol (3), ${\beta}-sitosterol-O-{$\beta}-D-glucoside$ (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.

Keywords

References

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