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The Pharmaceutical Society of Korea (대한약학회)
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HIV-1 Integrate Inhibitory Phenylpropanoid Glycosides from Clerodendron trichotomum

  • Kim, Hyoung-Ja (Division of Life Science, Korea Institute of Science ＆ Technology) ;
  • Woo, Eun-Rhan (Division of Life Science, Korea Institute of Science ＆ Technology and College of Pharmacy, Chosun University) ;
  • Shin, Cha-Gyun (Department of Biotechnology, Chung Ang University) ;
  • Hwang, Dong-Jin (Division of Life Science, Korea Institute of Science ＆ Technology) ;
  • Park, Ho-koon (Division of Life Science, Korea Institute of Science ＆ Technology) ;
  • Lee, Yong-Sup (Division of Life Science, Korea Institute of Science ＆ Technology)
  • Published : 2001.08.01
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Abstract

Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HlV-1 integrase with $IC_{20}$ values of 7.8 ${\pm}$ 3.6 and 13.7 ${\pm}$ 6.0${\mu}\textrm{M}$, respectively.

Keywords

References

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