Archives of Pharmacal Research

  • 제24권3호
  • /
  • Pages.214-218
  • /
  • 2001
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Comparisons between White Ginseng Radix and Rootlet for Antidiabetic Activity and Mechanism in KKAy Mice

  • 발행 : 2001.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Cinseng Radix Palva, GRP) were investigated. After a four week oral administration, the fasting blood glucose levels in the GRA- and GRP-treated groups were lower when compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activities, in addition to PPAR-${\gamma}$ expression in adipose tissue were examined. The results strongly suggest that GRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal glucose absorption and inhibiting hepatic glucose-6-phosphatase, and GRP through the upregulation of adipocytic PPAR-$\gamma$ protein expression as well as inhibiting intestinal glucose absorption.

키워드

참고문헌

  1. Meth. Enzy. Anal. v.2 Baginki,E.S.;Foa,P.;Zak,B.
  2. J. Physiol. v.171 Electrical potentials associated with intestinal sugar transfer Barry,R.J.C.;Dikstein,S.;Matthews,J.;Smyth,D.H.;Wright,E.M.
  3. Diabetic Med. v.16 Thiazolidinediones: a new class of antidiabetic drugs Day,C.
  4. Diabetes v.37 Lilly lecture 1987. The triumvirate: betacell, muscle, liver. A collusion responsible for NIDDM DeFronzo,R.A.
  5. Comparative Medicine East and West v.6 Effects of ginseng on the performance of nuses on night duty Hallstrom,C.;Fulder,S.;Carruthers,M.
  6. Diabetes v.43 Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM Jeng,C.Y.;Sheu,W.H.H.;Fuh,M.T.;Chen,Y.D.I.;Reaven,G.M.
  7. J. Biol. Chem. v.258 Studies on the mechnism by which exogenous glucose is converted into liver glycogen in the rat Newgard,C.B.;Hirsch,L.J.;Foster,D.W.;McGarry,J.D.
  8. Gen. Pharmac. v.16 Hypoglycemic constituents of Panax Ginseng Ng,T.B.;Yeung,H.W.
  9. Diabetologia v.33 On the determination of basal glucose production rate in patients with type 2 (non-insulin-dependent) diabetes mellitus using primed-continuous 3-3H-glucose infusion Nielson,H.;Beck,O.;Nilson,H.
  10. American J. Chi, Med. v.27 Effects of ginseng radix on sugar absorption in the small intestine Onomura,M.;Tsukada,H.;Fukuda,K.;Hosokawa,M.;Nakamura,H.;Kodama,M.;Ohya,M.;Seino,Y.
  11. Zeitschrift fur Phytotherapie v.11 Ginseng (Panax ginseng C. A. Meyer) Sonnenborn,U.;Proppert,Y.
  12. Diabetes Care v.18 no.10 Ginseng therapy in non-insulin-dependent diabetic patients Sotaniemi,E.A.;Haapakoski,E.;Rautio,A.
  13. Diabetes v.46 PPAR-γ: adipogenic regulator and thiazolidinedione receptor Spiegelman,B.M.
  14. Annal. Clin. Biochem. v.6 Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor Trinder,T.
  15. Chem. Pharm. Bull. v.33 Hyperlipemia-improving effects of ginsenoside-Rb2 in streptozotocin-diabetic rats Yokozawa,T.;Kobayashi,T.;Oura,H.;Kawashima,Y.
  16. J. Yonago Med. Assoc. v.37 Inhibitory effect of gymnemic acid and an extract from the leaves of Zizyphus jujuba on glucose absorption in the rat small intestine Yoshioka,S.