Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Naphthazarin Derivatives (Ⅶ): Antitumor Action against ICR Mice Bearing Ascitic S-780 Cells

  • Song, Gyu-Yong (College of Pharmacy, Chungnam National University) ;
  • Kim, Yong (College of Pharmacy, Chungnam National University) ;
  • You, Young-Jae (College of Pharmacy, Chungnam National University) ;
  • Cho, Hoon (Kuhnil Pharmaceutical Co (LTD)) ;
  • Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
  • Published : 2001.06.01
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Abstract

Various analogues of 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) such as 2- or 6-(1-hydroxyiminoalkyl)-DMNQs were prepared and evaluated for the antitumor action. (1 -Hydroxyiminoalkyl)-DMNQs derivatives expressed greater antitumor action than (1-hydroxyalkyl) - or acyl-DMNQ derivatives. Moreover, 6-(1-hydroxyiminoalkyl)-DMNQ derivatives expressed higher antitumor action than 2-substituted ones, suggestive of a steric effect. Some of 6-(1-propyloxyalkyl)-DMNQ derivatives with an alkyl group of butyl to octyl moiety showed T/C values of >400%

Keywords

References

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