Archives of Pharmacal Research
- 제24권2호
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- Pages.150-158
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- 2001
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Inhibition of Heat-induced Denaturation of Albumin by Nonsteroidal Antiinflammatory Drugs (NSAIDs): Pharmacological Implications
- Luciano-Saso (Department of Pharmacology of National Substances and General Physiology, University of Rome ″La Sapienza″) ;
- Giovanni-Valentini (Department of Pharmacology of National Substances and General Physiology, University of Rome ″La Sapienza″) ;
- Casini, Maria-Luisa (Department of Pharmacology of National Substances and General Physiology, University of Rome ″La Sapienza″) ;
- Eleonora-Grippa (Department of Pharmacology of National Substances and General Physiology, University of Rome ″La Sapienza″) ;
- Gatto, Maria-Teresa (Department of Pharmacology of National Substances and General Physiology, University of Rome ″La Sapienza″) ;
- Leone, Maria-Grazia (Department of Pharmacology of National Substances and General Physiology, University of Rome ″La Sapienza″) ;
- Bruno-Silvestrini (Department of Pharmacology of National Substances and General Physiology, University of Rome ″La Sapienza″)
- 발행 : 2001.04.01
초록
The activity of nonsteroidal antiinflammatory drugs (NSAIDs) in rheumatoid arthritis is not only due to the inhibition of the production of prostaglandins, which can even have beneficial immunosuppressive effects in chronic inflammatory processes. Since we speculated that these drugs could also act by protecting endogenous proteins against denaturation, we evaluated their effect on heat-induced denaturation human serum albumin (HSA) in comparison with several fatty acids which are known to be potent stabilizers of this protein. By the Mizushimas assay and a recently developed HPLC assays we observed that NSAIDs were slightly less active [
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