YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis of Potential Antiinfammatory Benzisothiazoline Derivatives

잠재성 항염효과가 있는 벤즈이소티아졸린 유도체의 합성

  • 박명숙 (덕성여자대학교 약학대학) ;
  • 윤명선 (덕성여자대학교 약학대학) ;
  • 김미경 (덕성여자대학교 약학대학) ;
  • 권순경 (덕성여자대학교 약학대학)
  • Published : 2001.12.01
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Abstract

In order to discover new useful NSAIDs, novel N-substituted 1,2-benzisothiazoline-3-one 1,1- dioxide derivatives, which can exhibit potentially antiinflammatory activity were synthesized. 1,2-Benz-isothiazoline-3-one-N-acetic acids 6a, b were obtained from monochloroacetic acid and sodium 1,2-benz-isothiazoline-3-ones in DMF by N-alkylation reaction. N-Substituted 1,2-benzisothiazoline-3-one 1,1-dioxide derivatives 7a-e were synthesized through the coupling of compound 6a, b and several amines (aniline, 2- aminopyridine , 2-aminothiazole, 2-aminotetrazole) with dicyclohexylcarbodiimide in methyl e no chloride.

Keywords

References

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